Alice Bertero

TL;DR: The molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine are discussed.

TL;DR: In this paper, the authors used resting state functional MRI data from the Simons Variation in Individuals Project (VIP) database to identify variants that increase risk for neurodevelopmental disorders and suggest that deletion in 16p11.2 may lead to impaired socio-cognitive function via dysregulation of prefrontal connectivity.

TL;DR: Findings reveal a key contribution of ASD-associated gene CNTNAP2 in modulating macroscale functional connectivity, and suggest that homozygous loss-of-function mutations in this gene may predispose to neurodevelopmental disorders and autism through a selective dysregulation of connectivity in integrative prefrontal areas.

TL;DR: It is shown that acallosal BTBR T+tpr3tf/J (BTBR) mice, an idiopathic model of autism, exhibit impaired intra-hemispheric connectivity in fronto-cortical, but not in posterior sensory cortical areas, and the observed long-range connectivity impairments recapitulate hallmark neuroimaging findings in autism.

TL;DR: The results reveal a critical role of SHank3 in the development of prefrontal anatomy and function, and suggest that SHANK3 deficiency may predispose to intellectual disability and socio-communicative impairments via dysregulation of higher-order cortical connectivity.