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Alicia Colombo
Researcher at University of Chile
Publications - 34
Citations - 775
Alicia Colombo is an academic researcher from University of Chile. The author has contributed to research in topics: Population & Gene. The author has an hindex of 15, co-authored 31 publications receiving 667 citations.
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Journal ArticleDOI
ALS-linked protein disulfide isomerase variants cause motor dysfunction.
Ute Woehlbier,Ute Woehlbier,Alicia Colombo,Mirva J. Saaranen,Viviana Pérez,Jorge Ojeda,Fernando J. Bustos,Catherine I. Andreu,Mauricio Torres,Vicente Valenzuela,Danilo B. Medinas,Pablo Rozas,Rene L. Vidal,Rodrigo Lopez-Gonzalez,Johnny Salameh,Sara Fernandez-Collemann,Natalia Muñoz,Soledad Matus,Ricardo Armisen,Alfredo Sagredo,Karina Palma,Thergiory Irrazabal,Sandra Almeida,Paloma Gonzalez-Perez,Mario Campero,Mario Campero,Fen-Biao Gao,Pablo Henny,Brigitte van Zundert,Lloyd W. Ruddock,Miguel L. Concha,Juan Pablo Henríquez,Robert H. Brown,Claudio Hetz +33 more
TL;DR: This study functionally characterized four ALS‐linked mutations recently identified in two major PDI genes, PDIA1 and PDIA3/ERp57, and identified ER proteostasis imbalance as a risk factor for ALS, driving initial stages of the disease.
Journal ArticleDOI
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
Diego Rojas-Rivera,Ricardo Armisen,Alicia Colombo,Gabriela Martínez,Ana Luisa Eguiguren,A Díaz,Santeri Kiviluoto,Diego A. Rodriguez,Maria Patron,Rosario Rizzuto,Geert Bultynck,Miguel L. Concha,Jimena Sierralta,Andrés Stutzin,Claudio Hetz +14 more
TL;DR: The function of TMBIM3/GRINA in the control of cell death by endoplasmic reticulum (ER) stress is reported and the existence of a conserved group of functionally related cell death regulators across species beyond the BCL-2 family of proteins operating at the ER membrane is suggested.
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Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetry
Iskra A. Signore,Néstor Guerrero,Felix Loosli,Alicia Colombo,Aldo Villalón,Joachim Wittbrodt,Miguel L. Concha +6 more
TL;DR: The usefulness of zebrafish and medaka as comparative models to study the developmental mechanisms of epithalamic asymmetry in vertebrates are highlighted and new tools for developmental time comparison among species are offered.
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TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility
Mónica Cáceres,Liliana Ortiz,Tatiana Recabarren,Anibal Romero,Alicia Colombo,Elías Leiva-Salcedo,Diego Varela,José Rivas,Ian Silva,Diego Morales,Camilo Campusano,Oscar Almarza,Felipe Simon,Héctor Toledo,Kang Sik Park,James S. Trimmer,Oscar Cerda,Oscar Cerda +17 more
TL;DR: These findings provide the first evidence, to the authors' knowledge, for a TRP channel specifically localized to focal adhesions, where it performs a central role in modulating cellular migration and contractility.
Journal ArticleDOI
Mechanisms of directional asymmetry in the zebrafish epithalamus.
TL;DR: A sequential modular organisation of the events controlling the development of asymmetry along the parapineal-habenular-interpeduncular axis is proposed.