J
James S. Trimmer
Researcher at University of California, Davis
Publications - 212
Citations - 19144
James S. Trimmer is an academic researcher from University of California, Davis. The author has contributed to research in topics: Potassium channel & Ion channel. The author has an hindex of 73, co-authored 203 publications receiving 17755 citations. Previous affiliations of James S. Trimmer include University of Minnesota & University of Iowa.
Papers
More filters
Journal ArticleDOI
Modulation of A-type potassium channels by a family of calcium sensors
An Wenqian,Mark R. Bowlby,M. Betty,Jie Cao,Huai-ping Ling,G. Mendoza,J. W. Hinson,K. I. Mattsson,Brian W. Strassle,James S. Trimmer,Kenneth J. Rhodes +10 more
TL;DR: Three Kv channel-interacting proteins (KChIPs) that bind to the cytoplasmic amino termini of Kv4 α-subunits are described that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
Journal ArticleDOI
Outward K+ Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation
TL;DR: The unexpected finding of reduced voltage-gated outward K+ current densities in atrial myocytes from AF patients demonstrates the need to further examine the details of the electrophysiological remodeling that occurs during AF to enable more effective and safer therapeutic strategies to be developed.
Journal ArticleDOI
Primary structure and functional expression of a mammalian skeletal muscle sodium channel
James S. Trimmer,Sharon S. Cooperman,Sally A. Tomiko,Jiuying Zhou,Shelia M. Crean,Mary B. Boyle,Roland G. Kalen,Zu-Hang Sheng,Robert L. Barchi,Fred J. Sigworth,Richard H. Goodman,William S. Agnew,Gail Mandel +12 more
TL;DR: The isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle is described, and northern blot analysis indicates that the 8.5 kb microI transcript is preferentially expressed in skeletal muscle.
Journal ArticleDOI
Caspr2, a New Member of the Neurexin Superfamily, Is Localized at the Juxtaparanodes of Myelinated Axons and Associates with K+ Channels
Sebastian Poliak,Leora Gollan,Ricardo Martinez,Andrew W. Custer,Steven Einheber,James L. Salzer,James S. Trimmer,Peter Shrager,Elior Peles +8 more
TL;DR: A role for Caspr family members in the local differentiation of the axon into distinct functional subdomains is suggested in the generation of specialized subcellular domains to which different sets of ion channels are localized.
Journal ArticleDOI
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.
TL;DR: Progress made on recent studies aimed to determine the cellular and subcellular distribution of specific ion channel subunits in mammalian brain neurons using in situ hybridization and immunohistochemistry are reviewed.