A
Alisa Littau
Publications - 2
Citations - 1947
Alisa Littau is an academic researcher. The author has contributed to research in topics: B-cell activating factor & Transmembrane activator and CAML interactor. The author has an hindex of 2, co-authored 2 publications receiving 1900 citations.
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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Jane A. Gross,Janet V. Johnston,Sherri Mudri,Rachel Enselman,Stacey R. Dillon,Karen L. Madden,Wenfeng Xu,Julia Parrish-Novak,Don Foster,Catherine Lofton-Day,Margaret D. Moore,Alisa Littau,Angelika Grossman,Harald S. Haugen,Kevin P. Foley,Hal Blumberg,Kim Harrison,Wayne R. Kindsvogel,Christopher H. Clegg +18 more
TL;DR: These findings demonstrate the involvement of zTNF4 and its receptors in the development of SLE and identify TACI–Ig as a promising treatment of autoimmune disease in humans.
Journal ArticleDOI
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.
Jane A. Gross,Stacey R. Dillon,Sherri Mudri,Janet V. Johnston,Alisa Littau,Richard Roque,Mark W. Rixon,Ole Schou,Kevin P. Foley,Harald S. Haugen,Susan McMillen,Kim Waggie,Randy W Schreckhise,Kim Shoemaker,Tuyen Vu,Margaret D. Moore,Angelika Grossman,Chris Clegg +17 more
TL;DR: It is suggested that BLyS is required for the development of most but not all mature B cell populations found in the periphery, while B-1 cell numbers are relatively normal inBLyS-deficient mice.