Richard Roque

TL;DR: It is suggested that BLyS is required for the development of most but not all mature B cell populations found in the periphery, while B-1 cell numbers are relatively normal inBLyS-deficient mice.

TL;DR: A combination of two mAbs that simultaneously bind to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2 are described and AZD7442 is projected to contribute to long-term human protection.

TL;DR: Protection against avian flu is tested by using H5N1-derived rHA and GLA-SE and a two-part adjuvant system containing glucopyranosyl lipid adjUvant (GLA), a formulated synthetic Toll-like receptor 4 agonist, and a stable emulsion of oil in water, which is similar to the best-in-class adjuvants being developed for pandemic flu.

TL;DR: A simple lipid-based aqueous formulation containing a synthetic TLR4 ligand (GLA-AF) was very effective in adjuvanting recombinant H5 hemagglutinin antigen in mice and was as potent as the stable emulsion, SE, which warrants consideration for pandemic influenza vaccine development.

TL;DR: A short trimeric coiled-coil peptide is synthesized that creates a series of B and T cell epitopes with uniform stoichiometry and high density that resulted in a nicotine binding capacity in serum that could prevent >90% of a nicotine dose equivalent to three smoked cigarettes from reaching the brain.