A
Alison J. Hurst
Researcher at University of Exeter
Publications - 14
Citations - 1161
Alison J. Hurst is an academic researcher from University of Exeter. The author has contributed to research in topics: Single-nucleotide polymorphism & Minor allele frequency. The author has an hindex of 10, co-authored 14 publications receiving 1060 citations. Previous affiliations of Alison J. Hurst include Peninsula College of Medicine and Dentistry.
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Journal ArticleDOI
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
David Melzer,John R. B. Perry,Dena G. Hernandez,Annamaria Corsi,Kara Stevens,Ian Rafferty,Fulvio Lauretani,Anna Murray,J. Raphael Gibbs,Giuseppe Paolisso,Sajjad Rafiq,Javier Simón-Sánchez,Hana Lango,Sonja W. Scholz,Michael N. Weedon,Sampath Arepalli,Neil Rice,Nicole Washecka,Alison J. Hurst,Angela Britton,William Henley,Joyce van de Leemput,Rongling Li,Anne B. Newman,Gregory J. Tranah,Tamara B. Harris,Vijay Panicker,Vijay Panicker,Colin M. Dayan,Amanda J. Bennett,Mark I. McCarthy,Aimo Ruokonen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jack M. Guralnik,Stefania Bandinelli,Timothy M. Frayling,Andrew B. Singleton,Luigi Ferrucci +38 more
TL;DR: It is shown that common genetic variation influences levels of clinically relevant proteins in human serum and plasma and the identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving the understanding of disease pathways.
Journal ArticleDOI
A common variant of the interleukin 6 receptor ( IL-6r ) gene increases IL-6r and IL-6 levels, without other inflammatory effects
Sajjad Rafiq,Timothy M. Frayling,Anna Murray,Alison J. Hurst,Kara Stevens,Michael N. Weedon,William Henley,Luigi Ferrucci,Stefania Bandinelli,Annamaria Corsi,J. M. Guralnik,David Melzer +11 more
TL;DR: A common variant of the IL- 6r gene results in major changes in IL-6r andIL-6 serum levels, but with no apparent effect on gp130 levels or on inflammatory status in the general population.
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Systematic review and meta-analysis of the association between childhood overweight and obesity and primary school diet and physical activity policies.
Andrew James Williams,Andrew James Williams,William Henley,Craig A. Williams,Alison J. Hurst,Stuart Logan,Katrina Wyatt +6 more
TL;DR: The evidence suggests that, when implemented alone, school diet and physical activity related policies appear insufficient to prevent or treat overweight or obesity in children, however, they do appear to have an effect when developed and implemented as part of a more extensive intervention programme.
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Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.
Sajjad Rafiq,Kara Stevens,Alison J. Hurst,Anna Murray,William Henley,Michael N. Weedon,Stefania Bandinelli,Annamaria Corsi,J. M. Guralnik,Luigi Ferruci,David Melzer,Timothy M. Frayling +11 more
TL;DR: Genotyped seven single nucleotide polymorphisms that capture a large proportion of common genetic variation in the IL-1RN gene and found suggestive evidence that the C allele at rs4251961 that lowers IL- 1RA levels is associated with an increasedIL-1β level and may also be associated with interferon -γ level.
Journal ArticleDOI
Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
David Melzer,Anna Murray,Alison J. Hurst,Michael N. Weedon,Stefania Bandinelli,Anna Maria Corsi,Luigi Ferrucci,Guiseppe Paolisso,Jack M. Guralnik,Timothy M. Frayling +9 more
TL;DR: The TCF7L2 rs7903146 polymorphism is associated with lower insulin levels, smaller waist circumference, and lower risk lipid profiles in the general elderly population, and may have implications for developing treatment approaches tailored by genotype.