Allan L. Sherwin

TL;DR: The results indicate that the increased incidence of congenital malformations was caused primarily by AEDs, suggesting that mal Formations can be prevented by improvements in drug regimen, and by avoiding polypharmacy and high levels of VPA in the treatment of epileptic women of childbearimg age.

TL;DR: A comparison of the amino acid levels in focal and surrounding tissue of the same patient demonstrated that the focal area most often contained the lowest concentrations of glutamic acid, aspartic acid and taurine in combination with the highest glycine content.

TL;DR: Patients with Rasmussen's syndrome treated with intravenous immunoglobulins, high-dose steroids, or both to control seizures and improve the end point of the disease had some reduction of seizure frequency in the short term.

TL;DR: Cortical epileptic activity appears to be associated with elevated concentrations of glutamate, aspartate, and glycine, but not GABA and taurine, perhaps indicating a relative imbalance between putative excitatory and inhibitory amino acid neurotransmitters.

TL;DR: Nuclear magnetic resonance spectroscopy reveals that patients with poorly controlled complex partial seizures have a significant diminution in occipital lobe gamma aminobutyric acid (GABA) concentration, and NMRS studies show that vigabatrin, a GABA-T inhibitor and effective antiepileptic, significantly increases brain GABA.