M
Miguel A. Cortez
Researcher at University of Toronto
Publications - 82
Citations - 3356
Miguel A. Cortez is an academic researcher from University of Toronto. The author has contributed to research in topics: Epilepsy & Atypical absence seizures. The author has an hindex of 32, co-authored 81 publications receiving 3015 citations. Previous affiliations of Miguel A. Cortez include Hospital for Sick Children & Mental Health Research Institute.
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Journal ArticleDOI
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
David Ng,Graham M. Pitcher,Graham M. Pitcher,Rachel K. Szilard,Andréa Sertié,Marijana Kanisek,Marijana Kanisek,Steven J. Clapcote,Tatiana V. Lipina,Lorraine V. Kalia,Lorraine V. Kalia,Daisy Joo,Colin McKerlie,Miguel A. Cortez,John C. Roder,John C. Roder,Michael W. Salter,Michael W. Salter,Roderick R. McInnes +18 more
TL;DR: The principle that auxiliary proteins are required for the normal abundance of NMDAR subunits at synapses is established, and it is demonstrated that an inherited learning defect can be rescued pharmacologically, a finding with therapeutic implications for humans.
Journal ArticleDOI
Medical treatment of Rasmussen's syndrome (chronic encephalitis and epilepsy) : effect of high-dose steroids or immunoglobulins in 19 patients
Y. M. Hart,Miguel A. Cortez,F. Andermann,Paul A. Hwang,D. R. Fish,Olivier Dulac,Kenneth Silver,Natalio Fejerman,H. Cross,Allan L. Sherwin,R. Caraballo +10 more
TL;DR: Patients with Rasmussen's syndrome treated with intravenous immunoglobulins, high-dose steroids, or both to control seizures and improve the end point of the disease had some reduction of seizure frequency in the short term.
Journal ArticleDOI
Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet.
Sergei S. Likhodii,Irina Serbanescu,Miguel A. Cortez,Patricia Murphy,O. Carter Snead,W. McIntyre Burnham +5 more
TL;DR: Elevation of brain acetone therefore may account for the efficacy of the KD in intractable epilepsy, and appears to have a broad spectrum of anticonvulsant effects.
Journal ArticleDOI
Mutation I810N in the α3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
Steven J. Clapcote,Steven Duffy,Gang Xie,Greer S. Kirshenbaum,Allison R. Bechard,Vivien Rodacker Schack,Janne Petersen,Laleh Sinai,Bechara J. Saab,Jason P. Lerch,Berge A. Minassian,Cameron Ackerley,John G. Sled,Miguel A. Cortez,Jeffrey T. Henderson,Bente Vilsen,John C. Roder +16 more
TL;DR: The functional significance of the Na+,K+-ATPase α3 isoform in the control of epileptiform activity and seizure behavior is revealed and it is revealed that the epilepsy in Myk/+ mice and in vitro hyperexcitability could be prevented by delivery of additional copies of wild-type Na+K+.
Journal ArticleDOI
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
Greer S. Kirshenbaum,Steven J. Clapcote,Steven Duffy,Christian R. Burgess,Janne Petersen,Karolina J. Jarowek,Yeni H. Yücel,Miguel A. Cortez,O. Carter Snead,Bente Vilsen,John H. Peever,Martin R. Ralph,John C. Roder +12 more
TL;DR: It is shown that Myshkin mice carrying an inactivating mutation in the neuron-specific Na+,K+-ATPase α3 subunit display a behavioral profile remarkably similar to bipolar patients in the manic state.