A
Allan Z. Zhao
Researcher at Guangdong University of Technology
Publications - 78
Citations - 3965
Allan Z. Zhao is an academic researcher from Guangdong University of Technology. The author has contributed to research in topics: Leptin & Cancer. The author has an hindex of 30, co-authored 67 publications receiving 3444 citations. Previous affiliations of Allan Z. Zhao include University of Pittsburgh & University of Washington.
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Journal ArticleDOI
Induction of leptin resistance through direct interaction of C-reactive protein with leptin.
Ke Chen,Li Fanghong,Ji Li,Hongbo Cai,Steven C. Strom,Alessandro Bisello,David E. Kelley,Miriam Friedman-Einat,Gregory A. Skibinski,Mark A. McCrory,Alexander J. Szalai,Allan Z. Zhao +11 more
TL;DR: The presence in human blood of several serum leptin-interacting proteins (SLIPs), isolated by leptin-affinity chromatography and identified by mass spectrometry and immunochemical analysis, confirmed that one of the major SLIPs is C-reactive protein (CRP).
Journal ArticleDOI
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway
Dawn M. Juilfs,Hans-Jürgen Fülle,Allan Z. Zhao,Miles D. Houslay,David L. Garbers,Joseph A. Beavo +5 more
TL;DR: A subset of olfactory neurons that express the cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D (GC-D) are found, suggesting that cG MP in these neurons also can have an important regulatory function in Olfactory signaling.
Journal ArticleDOI
Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes
Allan Z. Zhao,Michi M. Shinohara,Daming Huang,Masami Shimizu,Hagit Eldar-Finkelman,Edwin G. Krebs,Joseph A. Beavo,Karin E. Bornfeldt +7 more
TL;DR: Leptin, like insulin, induces an intracellular signaling pathway in hepatocytes that culminates in cAMP degradation and an antagonism of the actions of glucagon.
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A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.
TL;DR: Results indicate that a PI3K–PDE3B–cAMP pathway interacting with the Janus kinase 2 (Jak2)–Stat3 pathway constitutes a critical component of leptin signaling in the hypothalamus.
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Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
TL;DR: The results demonstrate that one of the physiological effects of leptin, suppression of insulin secretion, is mediated through activation of PDE3B and suggest Pde3B as a mediator of leptin action in other tissues.