S
Steven C. Strom
Researcher at University of Pittsburgh
Publications - 7
Citations - 1097
Steven C. Strom is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Cellular differentiation & Regulation of gene expression. The author has an hindex of 6, co-authored 7 publications receiving 1046 citations.
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Journal ArticleDOI
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas
Jianhua Luo,Baoguo Ren,Sergei Keryanov,George C. Tseng,Uma N. M. Rao,Satdarshan P.S. Monga,Steven C. Strom,Anthony J. Demetris,Michael A. Nalesnik,Yan P. Yu,Sarangarajan Ranganathan,George K. Michalopoulos +11 more
TL;DR: It is found that HCC and adjacent non‐neoplastic cirrhotic tissue have considerable overlap in gene expression patterns compared to normal liver, and specific areas of the genome appear unstable in HCC.
Journal ArticleDOI
Induction of leptin resistance through direct interaction of C-reactive protein with leptin.
Ke Chen,Li Fanghong,Ji Li,Hongbo Cai,Steven C. Strom,Alessandro Bisello,David E. Kelley,Miriam Friedman-Einat,Gregory A. Skibinski,Mark A. McCrory,Alexander J. Szalai,Allan Z. Zhao +11 more
TL;DR: The presence in human blood of several serum leptin-interacting proteins (SLIPs), isolated by leptin-affinity chromatography and identified by mass spectrometry and immunochemical analysis, confirmed that one of the major SLIPs is C-reactive protein (CRP).
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Present status and perspectives of cell-based therapies for liver diseases
Andreas K. Nussler,Sarah König,Michael Ott,Etienne Sokal,Bruno Christ,Wolfgang E. Thasler,Marc Brulport,Geredn Gabelein,Wiebke Schormann,Maren Schulze,Ewa Ellis,Matthias Kraemer,Frank Nocken,Wolfgang E. Fleig,Michael Manns,Steven C. Strom,Jan G. Hengstler +16 more
TL;DR: The present status of cell based therapies for liver diseases and the possible role of stem cells in liver tissue repair are summarized to identify areas of future preclinical and clinical research.
Journal ArticleDOI
Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor.
George K. Michalopoulos,William C. Bowen,Valerie F. Zajac,Donna Beer-Stolz,Simon C. Watkins,Vsevolod E. Kostrubsky,Steven C. Strom +6 more
TL;DR: The results show that the mixed cultures of proliferating hepatocytes and nonparenchymal cells can reproduce the hallmark structures of hepatic histological architecture while maintaining differentiation and the capacity to proliferate.
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Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture.
Jeanine L. Page,Mary C. Johnson,Katy M. Olsavsky,Steven C. Strom,Helmut Zarbl,Curtis J. Omiecinski +5 more
TL;DR: The concept that ECM functions mechanistically to augment the differentiation character of primary human hepatocytes in culture by mediating a reduction in cellular stress response signaling and by enhancing gap junctional cell-cell communication is supported.