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Alyssa Sproles
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 20
Citations - 1679
Alyssa Sproles is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: T cell & Dendritic cell. The author has an hindex of 13, co-authored 20 publications receiving 1551 citations. Previous affiliations of Alyssa Sproles include University of Cincinnati & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
Ian P. Lewkowich,Nancy S. Herman,Kathleen W. Schleifer,Matthew P. Dance,Brian L. Chen,Krista Dienger,Alyssa Sproles,Jaimin S. Shah,Jörg Köhl,Yasmine Belkaid,Marsha Wills-Karp +10 more
TL;DR: Data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility.
Journal ArticleDOI
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
Stephane Lajoie,Ian P. Lewkowich,Yusuke Suzuki,Jennifer R. Clark,Alyssa Sproles,Krista Dienger,Alison L. Budelsky,Marsha Wills-Karp +7 more
TL;DR: It is demonstrated that IL-17A mediated severe airway hyperresponsiveness (AHR) in susceptible strains of mice by enhancing IL-13-driven responses, and a critical role for complement-mediated regulation of the IL-23–TH17 axis in severe asthma is demonstrated.
Journal ArticleDOI
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
Jörg Köhl,Ralf Baelder,Ian P. Lewkowich,Manoj K. Pandey,Heiko Hawlisch,Lihua Wang,Jennifer Best,Nancy S. Herman,Alyssa Sproles,Jörg Zwirner,Jeffrey A. Whitsett,Craig Gerard,Georgia Sfyroera,John D. Lambris,Marsha Wills-Karp +14 more
TL;DR: A dual role for C5a in allergic asthma is suggested, protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment.
Proceedings ArticleDOI
Complement-mediated Regulation Of The IL-17A Axis Is A Central Genetic Determinant Of The Severity Of Experimental Allergic Asthma
Stephane Lajoie,Ian P. Lewkowich,Jennifer R. Clark,Alyssa Sproles,Krista Dienger,Alison L. Budelsky,Marsha Wills-Karp +6 more
Journal ArticleDOI
Allergen Uptake, Activation, and IL-23 Production by Pulmonary Myeloid DCs Drives Airway Hyperresponsiveness in Asthma-Susceptible Mice
Ian P. Lewkowich,Stephane Lajoie,Jennifer R. Clark,Nancy S. Herman,Alyssa Sproles,Marsha Wills-Karp,Marsha Wills-Karp +6 more
TL;DR: Comparative phenotypic and functional analysis of pulmonary DC populations in mice susceptible (A/J), or resistant (C3H) to experimental asthma, revealed that susceptibility to airway hyperresponsiveness is associated with preferential myeloid DC (mDC) allergen uptake, and production of Th17-skewing cytokines (IL-6, IL-23), whereas resistance isassociated with increased allerGEN uptake by plasmacytoid DCs.