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Ian P. Lewkowich
Researcher at University of Cincinnati
Publications - 14
Citations - 588
Ian P. Lewkowich is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Asthma & Extinction (psychology). The author has an hindex of 7, co-authored 14 publications receiving 513 citations. Previous affiliations of Ian P. Lewkowich include Boston Children's Hospital & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
Jörg Köhl,Ralf Baelder,Ian P. Lewkowich,Manoj K. Pandey,Heiko Hawlisch,Lihua Wang,Jennifer Best,Nancy S. Herman,Alyssa Sproles,Jörg Zwirner,Jeffrey A. Whitsett,Craig Gerard,Georgia Sfyroera,John D. Lambris,Marsha Wills-Karp +14 more
TL;DR: A dual role for C5a in allergic asthma is suggested, protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment.
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Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway
TL;DR: The data suggest that blockade of the PD‐1/PD‐L1 pathway is not likely to be efficient at restoring exhausted T‐cell responses in aged hosts, although improving the responses ofPD‐1− T cells may prove to be a helpful strategy in enhancing primary responses.
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Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing Lung
Gang Chen,Huajing Wan,Fengming Luo,Liqian Zhang,Yan Xu,Ian P. Lewkowich,Marsha Wills-Karp,Jeffrey A. Whitsett +7 more
TL;DR: It is shown that Foxa2, expressed selectively in the respiratory epithelium, plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation and goblet cell differentiation.
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A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells
Xun Zhang,Ian P. Lewkowich,Gabriele Köhl,Jennifer R. Clark,Marsha Wills-Karp,Jörg Köhl,Jörg Köhl +6 more
TL;DR: C5a receptor (C 5aR)-targeting of C3aR-deficient mice during allergen sensitization not only reversed the protective effect but enhanced Th2 cytokine production, airway inflammation, and airway responsiveness, suggesting that the reduced allergic phenotype in C3AR- deficient mice results from protective C5aR signaling.
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Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear.
Lauren L. Vollmer,Sriparna Ghosal,Jennifer L. McGuire,Rebecca Ahlbrand,Ke-Yong Li,Joseph M. Santin,Christine Annette Ratliff-Rang,Luis Gustavo Alexandre Patrone,Jennifer Rush,Ian P. Lewkowich,James P. Herman,Robert W. Putnam,Renu Sah,Renu Sah +13 more
TL;DR: The data identify TDAG8-dependent microglial acid sensing as a unique chemosensor for detecting and translating hypercapnia to fear-associated behavioral and physiological responses, providing a novel mechanism for homeostatic threat detection of relevance to psychiatric conditions such as panic disorder.