A
Amanda J. Ray
Researcher at Newcastle University
Publications - 11
Citations - 1058
Amanda J. Ray is an academic researcher from Newcastle University. The author has contributed to research in topics: Melanocortin 1 receptor & Gene. The author has an hindex of 9, co-authored 11 publications receiving 1022 citations. Previous affiliations of Amanda J. Ray include University of Newcastle.
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Journal ArticleDOI
Evidence for Variable Selective Pressures at MC1R
Rosalind M. Harding,Eugene Healy,Amanda J. Ray,Nichola S. Ellis,Niamh Flanagan,Carol Todd,Craig Dixon,Antti Sajantila,Ian J. Jackson,Mark A. Birch-Machin,Jonathan L. Rees +10 more
TL;DR: It is concluded that MC1R is under strong functional constraint in Africa, where any diversion from eumelanin production (black pigmentation) appears to be evolutionarily deleterious.
Journal ArticleDOI
Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation
Niamh Flanagan,Eugene Healy,Amanda J. Ray,Sion Philips,Carole Todd,Ian J. Jackson,Mark A. Birch-Machin,Jonathan L. Rees +7 more
TL;DR: It is demonstrated that heterozygotes for two alleles, R151C and 537insC, have a significantly elevated risk of red hair and the data provide evidence for a dosage effect of MC1R variants on hair as well as skin colour.
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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair
Eugene Healy,Eugene Healy,Niamh Flannagan,Amanda J. Ray,Carole Todd,Ian J. Jackson,John N. S. Matthews,Mark A. Birch-Machin,Jonathan L Rees +8 more
TL;DR: Evidence of an association between the degree of tanning after repeated sun exposure, and the number of variant alleles present is found, suggesting that MC1R gene status therefore determines sun sensitivity in people without red hair.
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Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status.
Lisa Naysmith,Karen Waterston,Tom Ha,Niamh Flanagan,Yvonne Bisset,Amanda J. Ray,Kazumasa Wakamatsu,Shosuke Ito,Jonathan L. Rees +8 more
TL;DR: It is shown for one of the most polymorphic human traits that it is possible to demonstrate meaningful relations between various physical characteristics: DNA sequence diversity, hair-wavelength-specific reflectance patterns, and chemical melanin assays.
Journal ArticleDOI
The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin
TL;DR: The large spectrum of deletions identified in this study highlights the ubiquitous nature and the high mutational load of mitochondrial DNA associated with ultraviolet exposure and chronologic aging.