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Amandine Legat
Researcher at University of Lausanne
Publications - 9
Citations - 1635
Amandine Legat is an academic researcher from University of Lausanne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 9, co-authored 9 publications receiving 1420 citations. Previous affiliations of Amandine Legat include Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients
Lukas Baitsch,Petra Baumgaertner,Estelle Devevre,Sunil K. Raghav,Amandine Legat,Leticia Barba,Sébastien Wieckowski,Hanifa Bouzourene,Bart Deplancke,Pedro Romero,Nathalie Rufer,Daniel E. Speiser +11 more
TL;DR: The identified exhaustion profile revealed extended molecular alterations in Melan-A/MART-1-specific T cells isolated from metastases from patients with melanoma expressed a large variety of genes associated with T cell exhaustion.
Journal ArticleDOI
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
Daniel T. Utzschneider,Amandine Legat,Silvia A. Fuertes Marraco,Lucie Carrié,Immanuel F. Luescher,Daniel E. Speiser,Dietmar Zehn +6 more
TL;DR: It is proposed that during persistent infection, effector T cells stably differentiate into a state that is optimized to limit viral replication without causing overwhelming immunological pathology.
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Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.
TL;DR: This study studied the expression of inhibitory Receptors by CD8 T cells of healthy humans, and shows that many iRs are expressed upon activation, and with progressive differentiation to effector cells, even in absence of long-term (“chronic”) antigenic stimulation.
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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.
Lukas Baitsch,Amandine Legat,Leticia Barba,Silvia A. Fuertes Marraco,Jean-Paul Rivals,Petra Baumgaertner,Céline Christiansen-Jucht,Hanifa Bouzourene,Donata Rimoldi,Hanspeter Pircher,Nathalie Rufer,Maurice Matter,Olivier Michielin,Daniel E. Speiser +13 more
TL;DR: The data suggest that naive T-cells are primarily regulated by BTLA and TIM-3, whereas effector cells interact via larger numbers of inhibitory receptors, which may improve T-cell based therapies.
Journal ArticleDOI
The three main stumbling blocks for anticancer T cells.
TL;DR: In this article, the reversibility of T cell exhaustion and novel molecular insights provide the basis for further improvements of clinical immunotherapy, and state-of-the-art adoptive cell transfer and active immunotherapy can partially overcome the three stumbling blocks.