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Immanuel F. Luescher
Researcher at University of Lausanne
Publications - 145
Citations - 8660
Immanuel F. Luescher is an academic researcher from University of Lausanne. The author has contributed to research in topics: Cytotoxic T cell & T-cell receptor. The author has an hindex of 46, co-authored 144 publications receiving 8111 citations. Previous affiliations of Immanuel F. Luescher include Washington University in St. Louis & French Institute of Health and Medical Research.
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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients
Julien Fourcade,Zhaojun Sun,Mourad Benallaoua,Philippe Guillaume,Immanuel F. Luescher,Cindy Sander,John M. Kirkwood,Vijay K. Kuchroo,Hassane M. Zarour +8 more
TL;DR: These findings support the use of Tim-3–Tim-3L blockade together with PD-1–PD-L1 blockade to reverse tumor-induced T cell exhaustion/dysfunction in patients with advanced melanoma.
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A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.
Catia Traversari,P. van der Bruggen,Immanuel F. Luescher,Christophe Lurquin,Patrick Chomez,A Van Pel,E De Plaen,A Amar-Costesec,Thierry Boon +8 more
TL;DR: It is shown that CTL directed against this antigen, which was named MZ2-E, recognize a nonapeptide encoded by the third exon of gene MAGE-1, which opens the possibility of immunizing HLA-A1 patients whose tumor expresses Mage-1 either with the antigenic peptide or with autologous antigen-presenting cells pulsed with the peptide.
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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
Alexis M. Kalergis,Nicole Boucheron,Marie-Agnès Doucey,Edith Palmieri,Earl C. Goyarts,Zsuzsanna Vegh,Immanuel F. Luescher,Stanley G. Nathenson +7 more
TL;DR: The data indicate that efficient T cell activation occurs within an optimal dwell-time range of TCR-pMHC interaction, which is consistent with the exclusion of either extremely low or high affinity T cells from the expanded population during immune responses.
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CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
Julien Fourcade,Zhaojun Sun,Ornella Pagliano,Philippe Guillaume,Immanuel F. Luescher,Cindy Sander,John M. Kirkwood,Daniel Olive,Vijay K. Kuchroo,Hassane M. Zarour +9 more
TL;DR: These findings indicate that targeting BTLA along with the PD-1 and Tim-3 pathways is critical to reverse an important mechanism of immune escape in patients with advanced melanoma.
Journal ArticleDOI
CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes.
Immanuel F. Luescher,Eric Vivier,Andreas Layer,Jérôme Mahiou,François Godeau,Bernard Malissen,Pedro Romero +6 more
TL;DR: It is proposed that the ability of CD8 to act as coreceptor can be modulated by CD8–TCR interactions, and this work reports that the avidity of TCR–ligand interactions on cloned cytotoxic T cells is very greatly strengthened byCD8.