P
Pedro Romero
Researcher at University of Lausanne
Publications - 159
Citations - 13455
Pedro Romero is an academic researcher from University of Lausanne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 52, co-authored 158 publications receiving 11752 citations. Previous affiliations of Pedro Romero include Ludwig Institute for Cancer Research & Society for Immunotherapy of Cancer.
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Journal ArticleDOI
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
Journal ArticleDOI
Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape
Michael Hahne,Donata Rimoldi,Michael Schröter,Pedro Romero,M. Schreier,Lars E. French,Pascal Schneider,Thierry Bornand,Adriano Fontana,D. Lienard,Jean Charles Cerottini,J. Tschopp +11 more
TL;DR: In vivo, injection of FasL+ mouse melanoma cells in mice led to rapid tumor formation and tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL.
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Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients
Lukas Baitsch,Petra Baumgaertner,Estelle Devevre,Sunil K. Raghav,Amandine Legat,Leticia Barba,Sébastien Wieckowski,Hanifa Bouzourene,Bart Deplancke,Pedro Romero,Nathalie Rufer,Daniel E. Speiser +11 more
TL;DR: The identified exhaustion profile revealed extended molecular alterations in Melan-A/MART-1-specific T cells isolated from metastases from patients with melanoma expressed a large variety of genes associated with T cell exhaustion.
Journal ArticleDOI
Rapid and strong human CD8 + T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
Daniel E. Speiser,Danielle Liénard,Nathalie Rufer,Verena Rubio-Godoy,Donata Rimoldi,Ferdy Lejeune,Arthur M. Krieg,Jean-Charles Cerottini,Pedro Romero +8 more
TL;DR: CpG 7909 is an efficient vaccine adjuvant that promotes strong antigen-specific CD8+ T cell responses in humans, and in vitro, T cell clones recognized and killed melanoma cells in an antigen- specific manner.
Journal Article
Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues
Danila Valmori,Jean-François Fonteneau,Concepción Marañón Lizana,Nadine Gervois,Danielle Liénard,Danielle Liénard,Donata Rimoldi,Victor Jongeneel,Francine Jotereau,Jean Charles Cerottini,Jean Charles Cerottini,Pedro Romero,Pedro Romero +12 more
TL;DR: The results suggest that the Melan-A(26-35) peptide analogue ELAGIGILTV may be more immunogenic than the natural peptides in HLA-A*0201 melanoma patients and should thus be considered as a candidate for future peptide-based vaccine trials.