Amber Woolfenden

TL;DR: Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to bronchioalveolar stem cells as the putative cells of origin for this subtype of lung cancer.

TL;DR: The studies show that the genotype of tumor samples must be considered in studies to identify, characterize, and target tumor-propagating cells.

TL;DR: The model demonstrated that BASC proliferation and differentiation contributes between 0 and 25% of compensatory alveolar epithelial (type I and II cell) regrowth, demonstrating that regeneration requires a substantial contribution from AECII.

TL;DR: The recommended methods for conducting experiments with the mouse laser-induced CNV model are presented to enhance reproducibility and minimize investigator bias.

TL;DR: This work employed a high-throughput in vivo screening strategy with rodent models of choroidal neovascularization and iterative compound design to identify VEGFR-2 inhibitors with potential to benefit wet AMD patients, and these compounds demonstrate preferential ocular tissue distribution and efficacy after oral administration while minimizing systemic exposure.