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Amira T. Eldefrawi
Researcher at Cornell University
Publications - 42
Citations - 1500
Amira T. Eldefrawi is an academic researcher from Cornell University. The author has contributed to research in topics: Acetylcholine receptor & Acetylcholine. The author has an hindex of 25, co-authored 42 publications receiving 1492 citations. Previous affiliations of Amira T. Eldefrawi include University of Maryland, Baltimore & Ithaca College.
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Journal ArticleDOI
Purification and molecular properties of the acetylcholine receptor from Torpedo electroplax.
TL;DR: Binding of acetylcholine was totally inhibited by α-bungarotoxin or cobra toxin and was partially blocked by four nicotinic drugs, but not by two muscarinic ones.
Journal ArticleDOI
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.
Amira T. Eldefrawi,Mohyee E. Eldefrawi,Edson X. Albuquerque,Antonio Costa de Oliveira,Nabil A. Mansour,Michael Adler,John W. Daly,George B. Brown,Wolfgang Burgermeister,Bernhard Witkop +9 more
TL;DR: In membrane preparations from Torpedo electroplax, [3H]perhydrohistrionicotoxin bound reversibly to a limited number of high-affinity sites and presumably bound to an ion conductance modulator protein associated with the acetylcholine-receptor in intact membrane and readily separable from the receptor protein after solubilization.
Journal ArticleDOI
Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane.
Edson X. Albuquerque,Ming-Cheng Tsai,Robert S. Aronstam,Bernhard Witkop,Amira T. Eldefrawi,Mohyee E. Eldefrawi +5 more
TL;DR: The data suggest that PCP reacts with the electrogenic K(+) channel and the ionic channel associated with the AcCho receptor in the open as well as the closed conformation.
Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane (perhydrohistrionicotoxin/a-bungarotoxin/endplate current/acetylcholine noise/electric ray)
TL;DR: The effects of phencyclidine (PCP) on electrogenic and chemosensitive properties of the neuromuscular junction of skeletal muscle as well as on the binding sites on the acetylcholine (AcCho) receptor and its ionic channel in the electric organ memnbranes of the electric ray were studied in this article.
Journal ArticleDOI
Interaction between calcium and ligand-binding sites of the purified acetylcholine receptor studied by use of a fluorescent lanthanide
TL;DR: The results show that fluorescent lanthanides can be an important tool in such studies and whether the displacement of calcium by chemical mediators is directly responsible for activator-induced changes in ion permeability of neural membranes is an important question raised by the experiments.