Amit Chaudhary

TL;DR: It is demonstrated that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.

TL;DR: This article showed that global deletion or endothelial-specific deletion of GPR124 in mice results in embryonic lethality associated with abnormal angiogenesis of the forebrain and spinal cord.

TL;DR: It is shown that genetic disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma, breast, colon, and lung cancer and antibodies developed against the TEM8 extracellular domain blocked anthrax intoxication, inhibited tumor-induced angiogenesis, displayed broad antitumor activity, and augmented the activity of clinically approved anticancer agents without added toxicity.

TL;DR: Results show that water collected from inland canals and restricted circulation water bodies adjacent to heavily populated areas had high concentrations of multiple steroids, pharmaceuticals, and personal care products while open bay waters were largely devoid of the target analytes.

TL;DR: A formalism integrating PCA and generalized regression neural networks (GRNNs) is introduced in this paper and the effectiveness of the proposed modeling and monitoring formalism has been successfully demonstrated by conducting two case studies involving penicillin production and protein synthesis.