K
Kimberly D. Klarmann
Researcher at Leidos
Publications - 37
Citations - 1669
Kimberly D. Klarmann is an academic researcher from Leidos. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 19, co-authored 33 publications receiving 1402 citations. Previous affiliations of Kimberly D. Klarmann include Science Applications International Corporation & National Institutes of Health.
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Journal ArticleDOI
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
Steven Seaman,Zhongyu Zhu,Saurabh Saha,Xiaoyan M. Zhang,Mi Young Yang,Mary Beth Hilton,Karen Morris,Christopher S. Szot,Holly Morris,Deborah A. Swing,Lino Tessarollo,Sean W. Smith,Sylvia Degrado,Dmitry Borkin,Nareshkumar F. Jain,Julia Scheiermann,Yang Feng,Yanping Wang,Jinyu Li,Dean Welsch,Decrescenzo Gary A,Amit Chaudhary,Enrique Zudaire,Kimberly D. Klarmann,Jonathan R. Keller,Dimiter S. Dimitrov,Brad St. Croix +26 more
TL;DR: It is demonstrated that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
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Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation
Cyril Berthet,Kimberly D. Klarmann,Mary Beth Hilton,Hyung Chan Suh,Jonathan R. Keller,Hiroaki Kiyokawa,Philipp Kaldis +6 more
TL;DR: It is demonstrated that Cdk2 and Cdk4 cooperate to phosphorylate Rb in vivo and to couple the G1/S phase transition to mitosis via E2F-dependent regulation of gene expression.
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The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation.
Benyam Asefa,Kimberly D. Klarmann,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Jonathan R. Keller +5 more
TL;DR: The structure and biological activities of the IFI-200 proteins are described, and recent studies that describe their relevant roles in processes regulating cell proliferation and differentiation are discussed.
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Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells
Lei Sun,Lesley A. Mathews,Stephanie M. Cabarcas,Stephanie M. Cabarcas,Xiaohu Zhang,Xiaohu Zhang,Acong Yang,Ying Zhang,Matthew R. Young,Kimberly D. Klarmann,Jonathan R. Keller,William L. Farrar +11 more
TL;DR: A link between the classic NF‐κB signaling transduction pathway and the invasiveness of pancreatic CSCs is established, which may result in the identification of novel signals and molecules that function at an epigenetic level, and could potentially be targeted for pharmaceutical investigations and clinical trials.
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C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
Victoria Heath,Hyung Chan Suh,Matthew Holman,Katie Renn,John Gooya,Sarah Parkin,Kimberly D. Klarmann,Mariaestela Ortiz,Peter Johnson,Jonathan R. Keller +9 more
TL;DR: It is demonstrated that C/EBPalpha(-/-) fetal liver (FL) progenitors are hyperproliferative, show decreased differentiation potential, and show increased self-renewal capacity in response to hematopoietic growth factors (HGFs).