A
Amit Choudhary
Researcher at Broad Institute
Publications - 88
Citations - 2444
Amit Choudhary is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 66 publications receiving 1906 citations. Previous affiliations of Amit Choudhary include Harvard University & University of Wisconsin-Madison.
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Journal ArticleDOI
n → π * interactions in proteins
TL;DR: It is shown that an intimate interaction between backbone amides likewise arises from the delocalization of a lone pair of electrons from an oxygen atom to the antibonding orbital of the subsequent carbonyl group.
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Nature of Amide Carbonyl―Carbonyl Interactions in Proteins
TL;DR: The intimate interaction between adjacent carbonyl groups is shown to arise primarily from n→π* electronic delocalization, which has implications for organic, biological, and medicinal chemistry.
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Targeting the pancreatic β-cell to treat diabetes
TL;DR: An overview of the latest developments in the field of diabetes treatment by targeting the β-cell is provided, with an emphasis on the most promising strategies identified to date.
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An evaluation of peptide-bond isosteres.
Amit Choudhary,Ronald T. Raines +1 more
TL;DR: The ability of these isosteres to partake in noncovalent interactions is compared with that of the peptide bond and the consequential perturbations provide a useful tool for chemical biologists to reveal new structure–function relationships, and to endow peptides and proteins with desirable attributes.
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Multidimensional chemical control of CRISPR–Cas9
Basudeb Maji,Basudeb Maji,Basudeb Maji,Christopher L. Moore,Christopher L. Moore,Bernd Zetsche,Sara E. Volz,Feng Zhang,Matthew D. Shoulders,Matthew D. Shoulders,Amit Choudhary,Amit Choudhary,Amit Choudhary +12 more
TL;DR: In this paper, small-molecule-regulated protein degron domains are applied to both Cas9-mediated genome editing and transcriptional activities, which opens new avenues for systematic genome interrogation.