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Amit K. Das
Researcher at University of Texas Southwestern Medical Center
Publications - 16
Citations - 860
Amit K. Das is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Epidermal growth factor receptor & Population. The author has an hindex of 11, co-authored 16 publications receiving 778 citations. Previous affiliations of Amit K. Das include State University of New York System.
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Journal ArticleDOI
Non–Small Cell Lung Cancers with Kinase Domain Mutations in the Epidermal Growth Factor Receptor Are Sensitive to Ionizing Radiation
Amit K. Das,Mitsuo Sato,Michael D. Story,Michael Peyton,Robert Graves,Stella Redpath,Luc Girard,Adi F. Gazdar,Jerry W. Shay,John D. Minna,Chaitanya S. Nirodi +10 more
TL;DR: The majority of mutant EGFR NSCLCs, including those that contain the secondary gefitinib resistance T790M mutation, exhibit characteristics consistent with a radiosensitive phenotype, which include delayed DNA repair kinetics, defective IR-induced arrest in DNA synthesis or mitosis, and pronounced increases in apoptosis or micronuclei.
Journal ArticleDOI
Molecular genetics of palmitoyl-protein thioesterase deficiency in the U.S.
Amit K. Das,Carlos Becerra,Won Yi,Jui Yun Lu,Aristotle N. Siakotos,Krystyna E. Wisniewski,Sandra L. Hofmann +6 more
TL;DR: In 29 of the families, PPT deficiency was found to be responsible for the neurodegenerative disorder, and mutations were identified in 57 out of 58 PPT alleles, resulting in a broader spectrum of clinical presentations than previously seen in the Finnish population.
Journal ArticleDOI
Somatic mutations in the tyrosine kinase domain of Epidermal Growth Factor Receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
Amit K. Das,Benjamin P C Chen,Michael D. Story,Mitsuo Sato,John D. Minna,David J. Chen,Chaitanya S. Nirodi +6 more
TL;DR: This study has identified a subset of naturally occurring EGFR mutations that lack a critical radioprotective function of EGFR, providing valuable insights on how the EGFR mediates cell survival in response to radiation in NSCLC cell lines.
Journal ArticleDOI
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
TL;DR: In human patients, lung squamous cell carcinomas highly ex-pressing KDM5B respond poorly to radiation, so the use of Jumonji KDM inhibitors as potent radiosensitizers is proposed.
Journal ArticleDOI
Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.
TL;DR: It is shown that the active site serine in PPT1 is modified by a substrate analog of PMSF, hexadecylsulfonylfluoride (HDSF) in a specific and site-directed manner, suggesting a structural explanation as to why certain serine lipases are resistant to modification by commonly used serine-modifying reagents.