A
Amonrat Jumnainsong
Researcher at Khon Kaen University
Publications - 33
Citations - 1639
Amonrat Jumnainsong is an academic researcher from Khon Kaen University. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 10, co-authored 31 publications receiving 1396 citations. Previous affiliations of Amonrat Jumnainsong include Imperial College London & Mahidol University.
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Journal ArticleDOI
Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans
Wanwisa Dejnirattisai,Amonrat Jumnainsong,Naruthai Onsirisakul,Naruthai Onsirisakul,Patricia Fitton,Sirijitt Vasanawathana,Wannee Limpitikul,Chunya Puttikhunt,Carolyn Edwards,Thaneeya Duangchinda,Sunpetchuda Supasa,Kriangkrai Chawansuntati,Prida Malasit,Prida Malasit,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +16 more
TL;DR: It is proposed that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
Wanwisa Dejnirattisai,Wiyada Wongwiwat,Sunpetchuda Supasa,Sunpetchuda Supasa,Xiaokang Zhang,Xiaokang Zhang,Xinghong Dai,Alexander Rouvinsky,Alexander Rouvinsky,Amonrat Jumnainsong,Amonrat Jumnainsong,Carolyn Edwards,Nguyen Than Ha Quyen,Thaneeya Duangchinda,Jonathan M. Grimes,Wen-Yang Tsai,Chih Yun Lai,Wei-Kung Wang,Prida Malasit,Prida Malasit,Jeremy Farrar,Cameron P. Simmons,Z. Hong Zhou,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +27 more
TL;DR: The results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
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Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity
Claire M. Midgley,Aleksandra Flanagan,Hai Bac Tran,Wanwisa Dejnirattisai,Kriangkrai Chawansuntati,Amonrat Jumnainsong,Wiyada Wongwiwat,Thaneeya Duangchinda,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Jonathan M. Grimes,Gavin R. Screaton +11 more
TL;DR: The characterization of a mAb, 2H12, is reported, which is cross-reactive to all four serotypes in the dengue virus group and provides a structural basis for understanding Ab neutralization and enhancement of infection, which are crucial for the development of future d Dengue vaccines.
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High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection.
Wen-Yang Tsai,Chih-Yun Lai,Yi-Chieh Wu,Hong-En Lin,Carolyn Edwards,Amonrat Jumnainsong,Amonrat Jumnainsong,Srisakul Kliks,Scott B. Halstead,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton,Wei-Kung Wang,Wei-Kung Wang +13 more
TL;DR: The findings suggest that the weakly neutralizing GR anti-E Abs generated from primary DENV infection become potently neutralizing MAbs against the four serotypes after secondary infection.
Journal ArticleDOI
Lectin Switching During Dengue Virus Infection
Wanwisa Dejnirattisai,Andrew I. Webb,Vera S. F. Chan,Amonrat Jumnainsong,Andrew D. Davidson,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +7 more
TL;DR: The results reveal that differential glycosylation of dengue virus envelope protein is highly dependent on cell state and suggest that studies of virus tropism using virus prepared in insect cells or tumor cell lines should be interpreted with caution.