S
Sirijitt Vasanawathana
Researcher at Thailand Ministry of Public Health
Publications - 18
Citations - 2956
Sirijitt Vasanawathana is an academic researcher from Thailand Ministry of Public Health. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 11, co-authored 18 publications receiving 2629 citations.
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Journal ArticleDOI
Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans
Wanwisa Dejnirattisai,Amonrat Jumnainsong,Naruthai Onsirisakul,Naruthai Onsirisakul,Patricia Fitton,Sirijitt Vasanawathana,Wannee Limpitikul,Chunya Puttikhunt,Carolyn Edwards,Thaneeya Duangchinda,Sunpetchuda Supasa,Kriangkrai Chawansuntati,Prida Malasit,Prida Malasit,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +16 more
TL;DR: It is proposed that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.
Journal ArticleDOI
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
Juthathip Mongkolsapaya,Wanwisa Dejnirattisai,Xiao-Ning Xu,Sirijitt Vasanawathana,Nattaya Tangthawornchaikul,Aroonrung Chairunsri,Siraporn Sawasdivorn,Thaneeya Duangchinda,Tao Dong,Sarah Rowland-Jones,Pa-thai Yenchitsomanus,Andrew J. McMichael,Prida Malasit,Prida Malasit,Gavin R. Screaton +14 more
TL;DR: Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T- cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
Journal ArticleDOI
Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement.
Panisadee Avirutnan,Nuntaya Punyadee,Sansanee Noisakran,Chulaluk Komoltri,Somchai Thiemmeca,Kusuma Auethavornanan,Aroonroong Jairungsri,Rattiyaporn Kanlaya,Nattaya Tangthawornchaikul,Chunya Puttikhunt,Sa-Nga Pattanakitsakul,Pa-thai Yenchitsomanus,Juthathip Mongkolsapaya,Watchara Kasinrerk,Nopporn Sittisombut,Nopporn Sittisombut,Matthias Husmann,Maria Blettner,Sirijitt Vasanawathana,Sucharit Bhakdi,Prida Malasit +20 more
TL;DR: Complement activation mediated by NS1 leads to local and systemic generation of anaphylatoxins and SC5b-9, which may contribute to the pathogenesis of the vascular leakage that occurs in patients with DHF/DSS.
Journal ArticleDOI
MAIT cells are activated during human viral infections
B van Wilgenburg,I Scherwitzl,Edward C. Hutchinson,Tianqi Leng,Ayako Kurioka,C Kulicke,C de Lara,S L Cole,Sirijitt Vasanawathana,Wannee Limpitikul,Prida Malasit,Duncan Young,Laura Denney,Moore,Paolo Fabris,Maria Teresa Giordani,Ye Htun Oo,Stephen M. Laidlaw,Lynn B. Dustin,Ho L-P.,Fiona M. Thompson,Narayan Ramamurthy,Juthathip Mongkolsapaya,Christian B. Willberg,Gavin R. Screaton,Paul Klenerman +25 more
TL;DR: It is demonstrated that MAIT cells are activated following viral infections, and a potential role in both host defence and immunopathology is suggested.
Journal ArticleDOI
An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection
Claire M. Midgley,Martha Bajwa-Joseph,Sirijitt Vasanawathana,Wannee Limpitikul,Bridget Wills,Aleksandra Flanagan,Emily Waiyaiya,Hai Bac Tran,Alison E. Cowper,P Chotiyarnwong,P Chotiyarnwong,Jonathan M. Grimes,Sutee Yoksan,Prida Malasit,Prida Malasit,Cameron P. Simmons,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +18 more
TL;DR: A simple in vitro enzyme-linked immunosorbent assay (ELISA) is proposed to diagnose the original d Dengue infection in secondary dengue cases and show dramatic evidence of original antigenic sin in secondary infections both in terms of binding and enhancement activity.