J
Jonathan M. Grimes
Researcher at University of Oxford
Publications - 173
Citations - 13837
Jonathan M. Grimes is an academic researcher from University of Oxford. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 55, co-authored 166 publications receiving 12116 citations. Previous affiliations of Jonathan M. Grimes include University of Bristol & European Bioinformatics Institute.
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Journal ArticleDOI
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Yanchun Peng,Alexander J. Mentzer,G Liu,G Liu,X Yao,Z Yin,D Dong,D Dong,Wanwisa Dejnirattisai,T Rostron,P Supasa,C Liu,Cesar Lopez-Camacho,J Slon-Campos,Yuguang Zhao,David I. Stuart,Guido C. Paesen,Jonathan M. Grimes,Alfred A. Antson,Oliver W. Bayfield,Hawkins Dedp.,Ker D-S.,B Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,P Zhang,Christina Dold,Jeremy Ratcliff,Peter Simmonds,T I de Silva,Paul Sopp,Dannielle Wellington,U S Rajapaksa,Chen Y-L.,Mariolina Salio,Giorgio Napolitani,Wayne Paes,Persephone Borrow,Benedikt M. Kessler,J W Fry,N F Schwabe,Malcolm G Semple,Malcolm G Semple,J K Baillie,Shona C Moore,Openshaw Pjm.,M A Ansari,Susanna Dunachie,Eleanor Barnes,John Frater,G Kerr,Philip J. R. Goulder,T Lockett,R Levin,Y Zhang,Y Zhang,R Jing,Ho L-P.,Richard J. Cornall,Christopher P. Conlon,Paul Klenerman,Gavin R. Screaton,Juthathip Mongkolsapaya,Andrew J. McMichael,Julian C. Knight,Graham S. Ogg,Tao Dong +67 more
TL;DR: The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design.
Journal ArticleDOI
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Claire Palles,Jean-Baptiste Cazier,Kimberley Howarth,Enric Domingo,Angela M. Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,Estrella Guarino,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal-Carmona,Yusanne Ma,Kulvinder Kaur,Sara E. Dobbins,Ella Barclay,Maggie Gorman,Lynn Martin,Michal Kovac,Michal Kovac,Sean Humphray,Anneke Lucassen,Christopher Holmes,David Bentley,Peter Donnelly,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David J. Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen E. Kearsey,Huw Thomas,Gilean McVean,Richard S. Houlston,Ian Tomlinson +38 more
TL;DR: A recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain, predicted to cause a defect in the correction of mispaired bases inserted during DNA replication.
The atomic structure of bluetongue virus core
Jonathan M. Grimes,J.N. Burroughs,Patrice Gouet,J.M. Diprose,R. Malby,S. Zientras,Mertens Ppc.,David I. Stuart,G Stubbs +8 more
TL;DR: The structure of the core of the bluetongue virus has been determined at 3.5 resolution, revealing molecular details of mismatched symmetry as discussed by the authors, which is the largest structure yet determined by X-ray crystallography.
Journal ArticleDOI
The atomic structure of the bluetongue virus core
Jonathan M. Grimes,J. Nicholas Burroughs,Patrice Gouet,J.M. Diprose,J.M. Diprose,R. Malby,Stéphan Zientara,Peter P. C. Mertens,David I. Stuart +8 more
TL;DR: The structure of the core particle of bluetongue virus has been determined by X-ray crystallography at a resolution approaching 3.5 Å, and the atomic structure indicates how approximately 1,000 protein components self-assemble.
Journal ArticleDOI
A Mechanism for Initiating RNA-Dependent RNA Polymerization
TL;DR: The results provide a working model for the initiation of replication and transcription of double-stranded RNA viruses and flaviviruses and suggest a mechanism by which the incoming double-Stranded RNA is opened up to feed the template through to the active site, while the substrates enter by another route.