A
Andrew I. Webb
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 124
Citations - 6312
Andrew I. Webb is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Epitope. The author has an hindex of 34, co-authored 115 publications receiving 4671 citations. Previous affiliations of Andrew I. Webb include Monash University, Clayton campus & Imperial College London.
Papers
More filters
Journal ArticleDOI
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy,Peter E. Czabotar,Peter E. Czabotar,Joanne M Hildebrand,Joanne M Hildebrand,Isabelle S Lucet,Jian-Guo Zhang,Jian-Guo Zhang,Silvia Alvarez-Diaz,Silvia Alvarez-Diaz,Rowena S. Lewis,Rowena S. Lewis,Najoua Lalaoui,Najoua Lalaoui,Donald Metcalf,Donald Metcalf,Andrew I. Webb,Andrew I. Webb,Samuel N. Young,Samuel N. Young,Leila N. Varghese,Leila N. Varghese,Gillian M. Tannahill,Gillian M. Tannahill,Esme C. Hatchell,Esme C. Hatchell,Ian J. Majewski,Ian J. Majewski,Toru Okamoto,Toru Okamoto,Renwick C. J. Dobson,Renwick C. J. Dobson,Douglas J. Hilton,Douglas J. Hilton,Jeffrey J. Babon,Jeffrey J. Babon,Nicos A. Nicola,Nicos A. Nicola,Andreas Strasser,Andreas Strasser,John Silke,John Silke,Warren S. Alexander,Warren S. Alexander +43 more
TL;DR: Structural-guided mutation of the MLKL pseudoactive site resulted in constitutive, RIPK3-independent necroptosis, demonstrating that modification ofMLKL is essential for propagation of the ne croptosis pathway downstream of RIPK 3.
Journal ArticleDOI
Linear ubiquitination prevents inflammation and regulates immune signalling
Björn Gerlach,Stefanie M. Cordier,Anna C. Schmukle,Christoph H. Emmerich,Christoph H. Emmerich,Eva Rieser,Tobias L. Haas,Andrew I. Webb,James A Rickard,Holly Anderton,W. Wei-Lynn Wong,Ueli Nachbur,Lahiru Gangoda,Uwe Warnken,Anthony W. Purcell,John Silke,Henning Walczak,Henning Walczak +17 more
TL;DR: It is concluded that by enabling linear ubiquitination in the TNF receptor signalling complex, SHARPIN interferes with TNF-induced cell death and, thereby, prevents inflammation.
Journal ArticleDOI
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M Hildebrand,Maria C. Tanzer,Isabelle S Lucet,Isabelle S Lucet,Samuel N. Young,Sukhdeep Kaur. Spall,Pooja Sharma,Catia L Pierotti,Jean-Marc Garnier,Renwick C. J. Dobson,Renwick C. J. Dobson,Andrew I. Webb,Anne Tripaydonis,Jeffrey J. Babon,Mark D. Mulcair,Martin J. Scanlon,Warren S. Alexander,Andrew F. Wilks,Peter E. Czabotar,Guillaume Lessene,Guillaume Lessene,James M. Murphy,John Silke +22 more
TL;DR: It is shown that the MLKL pseudokinase domain acts as a latch to restrain the N-terminal four-helix bundle (4HB) domain and that unleashing this domain results in formation of a high-molecular-weight, membrane-localized complex and cell death.
Journal ArticleDOI
CIS is a potent checkpoint in NK cell–mediated tumor immunity
Rebecca B. Delconte,Tatiana B. Kolesnik,Laura F. Dagley,Laura F. Dagley,Jai Rautela,Jai Rautela,Wei Shi,Wei Shi,Eva Maria Putz,Kimberley Stannard,Jian-Guo Zhang,Jian-Guo Zhang,Charis E Teh,Charis E Teh,Matthew A. Firth,Matthew A. Firth,Takashi Ushiki,Takashi Ushiki,Christopher E. Andoniou,Mariapia A. Degli-Esposti,Phillip P. Sharp,Phillip P. Sharp,C. Sanvitale,Giuseppe Infusini,Nicholas P. D. Liau,Nicholas P. D. Liau,Edmond M. Linossi,Edmond M. Linossi,Christopher J. Burns,Christopher J. Burns,Sebastian Carotta,Sebastian Carotta,Daniel H.D. Gray,Daniel H.D. Gray,Cyril Seillet,Cyril Seillet,Dana S. Hutchinson,Gabrielle T. Belz,Gabrielle T. Belz,Andrew I. Webb,Andrew I. Webb,Warren S. Alexander,Warren S. Alexander,Shawn S.-C. Li,Alex N. Bullock,Jeffery J. Babon,Jeffery J. Babon,Mark J. Smyth,Mark J. Smyth,Sandra E. Nicholson,Sandra E. Nicholson,Nicholas D. Huntington,Nicholas D. Huntington +52 more
TL;DR: This work has identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells, and uncovered a potent intracellular checkpoint in NK cell–mediated tumor immunity.
Journal ArticleDOI
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Seth L. Masters,Seth L. Masters,Vasiliki Lagou,Isabelle Jéru,Isabelle Jéru,Paul J. Baker,Paul J. Baker,Lien Van Eyck,David A. Parry,Dylan Lawless,Dominic De Nardo,Dominic De Nardo,Josselyn E. Garcia-Perez,Laura F. Dagley,Laura F. Dagley,Caroline L. Holley,James Dooley,Fiona Moghaddas,Fiona Moghaddas,Emanuela Pasciuto,Pierre-Yves Jeandel,Raf Sciot,Dena Lyras,Andrew I. Webb,Andrew I. Webb,Sandra E. Nicholson,Sandra E. Nicholson,Lien De Somer,Erika Van Nieuwenhove,Julia Ruuth-Praz,Bruno Copin,Emmanuelle Cochet,Myrna Medlej-Hashim,André Mégarbané,Kate Schroder,Sinisa Savic,An Goris,Serge Amselem,Serge Amselem,Carine Wouters,Adrian Liston +40 more
TL;DR: In this paper, a family with a dominantly inherited autoinflammatory disease, distinct from FMF, characterized by childhood-onset recurrent episodes of neutrophilic dermatosis, fever, elevated acute-phase reactants, arthralgia, and myalgia/myositis, was caused by a mutation in MEFV, the gene encoding pyrin (S242R).