Amy Berson

TL;DR: P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes and may have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.

TL;DR: Attention is focused on specific residues of P2X2 channel cytoplasmic domains as determinants of permeation in a state-specific manner to determine that two specific amino acid residues in the cytosolic tail domain govern this difference in behavior between the two orthologous channels.

TL;DR: The results suggest that NTR1 does not play a major role in the control of basal thermoregulation, nociception or psychomotor stimulation in mice (barring possible developmental plasticity), and does mediate these behavioral responses to NT agonists, and may play a role inThe potential antipsychotic effects of these agonists.

TL;DR: In this article, the efficacy of therapeutic drug candidates for the treatment of emphysema and/or COPD is evaluated, by determining biomarkers selected from the group SpB, desmosine, VEGF3 IGFBP2, MMP12, TIMPl,MMP9, Crabp2, Rbpl, Cyp26al, Tgm2, Timρ3, Adaml7, Serpinal, Slpi, Collal, EIn, TGFβl,TGFβ-RII, Sftpal, Csf2

TL;DR: A novel method to assay the pharmacodynamic (PD) properties of small-molecule and antibody inhibitors of CCR5 ligand-induced activation by measuring phosphorylation of serine residue 349 in the cytoplasmic tail of human C CR5 using phosphoflow cytometry in whole blood is reported.