H
Henry A. Lester
Researcher at California Institute of Technology
Publications - 423
Citations - 32349
Henry A. Lester is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Nicotinic agonist & Receptor. The author has an hindex of 96, co-authored 414 publications receiving 30984 citations. Previous affiliations of Henry A. Lester include Leipzig University & Rockefeller University.
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Journal ArticleDOI
Cloning and expression of a rat brain GABA transporter
John Guastella,Nathan Nelson,Hannah Nelson,Linda Czyzyk,Shoshi Keynan,May C. Miedel,Norman Davidson,Henry A. Lester,Baruch I. Kanner +8 more
TL;DR: Hydropathy analysis of the deduced protein suggests multiple transmembrane regions, a feature shared by several cloned transporters; however, database searches indicate that GAT-1 is not homologous to any previously identified proteins.
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Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization
Andrew R. Tapper,Sheri McKinney,Sheri McKinney,Sheri McKinney,Raad Nashmi,Raad Nashmi,Raad Nashmi,Johannes Schwarz,Johannes Schwarz,Johannes Schwarz,Purnima Deshpande,Purnima Deshpande,Purnima Deshpande,Cesar Labarca,Cesar Labarca,Cesar Labarca,Paul Whiteaker,Paul Whiteaker,Paul Whiteaker,Michael J. Marks,Michael J. Marks,Michael J. Marks,Allan C. Collins,Allan C. Collins,Allan C. Collins,Henry A. Lester,Henry A. Lester,Henry A. Lester +27 more
TL;DR: Activation of α4* nicotinic acetylcholine receptors with low doses of agonist recapitulates nicotine effects thought to be important in dependence, including reinforcement in response to acute nicotine administration, as well as tolerance and sensitization elicited by chronic nicotine administration.
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International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels
George A. Gutman,K. George Chandy,John P. Adelman,Jayashree Aiyar,Douglas A. Bayliss,David E. Clapham,Manuel Covarriubias,Gary V. Desir,Kiyoshi Furuichi,Barry Ganetzky,Maria L. Garcia,Stephan Grissmer,Lily Yeh Jan,Andreas Karschin,Donghee Kim,Sabina Kuperschmidt,Yoshihisa Kurachi,Michel Lazdunski,Florian Lesage,Henry A. Lester,David McKinnon,Colin G. Nichols,I. T. A. O'kelly,Jonathan Robbins,Gail A. Robertson,Bernardo Rudy,Michael C. Sanguinetti,Susumu Seino,Walter Stuehmer,Michael M. Tamkun,Carol A. Vandenberg,Aguan Wei,Heike Wulff,Randy S. Wymore +33 more
TL;DR: An overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels as mentioned in this paper.
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From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor
TL;DR: This finding indicates that, on binding, the cationic, quaternary ammonium group of acetylcholine makes van der Waals contact with the indole side chain of alpha tryptophan-149, providing the most precise structural information to date on this receptor.
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Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina
Paulo Kofuji,Paul W. Ceelen,Kathleen R. Zahs,Leslie W. Surbeck,Henry A. Lester,Eric A. Newman +5 more
TL;DR: Results indicate that Kir4.1 is the principal K+channel subunit expressed in mouse Müller glial cells and the involvement of this channel in the regulation of extracellular K+ in the mouse retina is indicated.