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Amy Koshoffer
Researcher at University of Cincinnati
Publications - 24
Citations - 841
Amy Koshoffer is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Melanocyte & Melanosome. The author has an hindex of 14, co-authored 23 publications receiving 750 citations. Previous affiliations of Amy Koshoffer include University of Cincinnati Academic Health Center & Center for Open Science.
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Journal ArticleDOI
Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
Ana Luisa Kadekaro,Sancy A. Leachman,Renny Kavanagh,Viki B. Swope,Pamela B. Cassidy,Dorothy M. Supp,Maureen A. Sartor,Sandy Schwemberger,George F. Babcock,Kazumasa Wakamatsu,Shosuke Ito,Amy Koshoffer,Raymond E. Boissy,Prashiela Manga,Richard A. Sturm,Zalfa A. Abdel-Malek +15 more
TL;DR: expression of 2 red hair variants abolished the response to α‐melanocortin and its photoprotective effects, evidenced by lack of functional coupling of the receptor, and absence of reduction in ultraviolet radiation‐induced hydrogen peroxide generation or enhancement of repair of DNA photoproducts, respectively.
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Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas
TL;DR: The breakpoints in the ELE1 and RET genes in 12 post-Chernobyl pediatric papillary carcinomas with known RET/PTC3 rearrangement were characterized, and it was found that the breakpoints within each intron were distributed in a relatively random fashion, except for clustering in the Alu regions of ELE1.
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Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible.
Amanda Greatens,Tomohiro Hakozaki,Tomohiro Hakozaki,Amy Koshoffer,Howard Epstein,Sandy Schwemberger,Sandy Schwemberger,George F. Babcock,George F. Babcock,Donald Lynn Bissett,Hirotsugu Takiwaki,Seiji Arase,R. Randall Wickett,Raymond E. Boissy +13 more
TL;DR: It is suggested that lectins and niacinamide at concentrations that do not affect cell viability are reversible inhibitors of melanosome transfer.
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Cellular defects in Chediak-Higashi syndrome correlate with the molecular genotype and clinical phenotype.
Wendy Westbroek,David H. Adams,Marjan Huizing,Amy Koshoffer,Heidi Dorward,Bradford Tinloy,Jennifer M. Parkes,Amanda Helip-Wooley,Robert Kleta,E.T. Tsilou,Patrice Duvernay,Kathleen B. Digre,Donnell J. Creel,James G. White,Raymond E. Boissy,William A. Gahl +15 more
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Monobenzyl Ether of Hydroquinone and 4-Tertiary Butyl Phenol Activate Markedly Different Physiological Responses in Melanocytes: Relevance to Skin Depigmentation
Vidhya Hariharan,Jared Klarquist,Mary J. Reust,Amy Koshoffer,Mark D. McKee,Raymond E. Boissy,I. Caroline Le Poole +6 more
TL;DR: Exposure to MBEH or 4-TBP has profoundly different consequences for melanocyte physiology and activates different death pathways, which help to explain the relative efficacy of these agents in mediating depigmentation.