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Amy R. Strom
Researcher at Lawrence Berkeley National Laboratory
Publications - 7
Citations - 1611
Amy R. Strom is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Chromatin & Biology. The author has an hindex of 2, co-authored 2 publications receiving 998 citations.
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Journal ArticleDOI
Phase separation drives heterochromatin domain formation
Amy R. Strom,Alexander Emelyanov,Mustafa Mir,Dmitry V. Fyodorov,Xavier Darzacq,Gary H. Karpen,Gary H. Karpen +6 more
TL;DR: It is proposed that emergent biophysical properties associated with phase-separated systems are critical to understanding the unusual behaviours of heterochromatin, and how chromatin domains in general regulate essential nuclear functions.
Journal ArticleDOI
Phase Separation Drives Heterochromatin Domain Formation
Amy R. Strom,Alexander Emelyanov,Mustafa Mir,Dmitry V. Fyodorov,Xavier Darzacq,Gary H. Karpen +5 more
TL;DR: In this article, it was shown that Drosophila HP1a protein undergoes liquid-liquid demixing in vitro, and nucleates into foci that display liquid properties during the early stages of heterochromatin domain formation in early Drosphila embryos, suggesting that the repressive action of H1 may be mediated in part by emergent properties of phase separation.
Journal ArticleDOI
Compartmentalization of Telomeres through DNA-scaffolded Phase Separation
Amanda Jack,Yoonji Kim,Amy R. Strom,Daniel S.W. Lee,Byron C. Williams,Jeffrey M. Schaub,Elizabeth A. Kellogg,Ilya J. Finkelstein,Luke S. Ferro,Ahmet Yildiz,Clifford P. Brangwynne +10 more
TL;DR: In this paper , the authors combine in vivo biophysical interrogation and in vitro reconstitution of human shelterin to understand how these dynamic components protect chromosome ends, and they show that shelterin components form multicomponent liquid condensates with selective biomolecular partitioning on telomeric DNA.
Journal ArticleDOI
The mechanobiology of nuclear phase separation
TL;DR: Recent developments on the role of phase separation and mechanics in nuclear organization are reviewed and the functional implications in cell physiology and disease states are discussed.
Posted ContentDOI
Condensate-driven interfacial forces reposition DNA loci and measure chromatin viscoelasticity
Amy R. Strom,Yoonji Kim,Hongbo Zhao,Natalia Orlovsky,Yi-Che Chang,Andrej Kosmrlj,Cornelis Storm,Clifford P. Brangwynne +7 more
TL;DR: VECTOR as mentioned in this paper uses light-inducible biomolecular condensates to generate capillary forces at targeted DNA loci, which can be used to programmably reposition genomic loci on a timescale of seconds to minutes.