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Ilya J. Finkelstein
Researcher at University of Texas at Austin
Publications - 121
Citations - 5665
Ilya J. Finkelstein is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: DNA & DNA repair. The author has an hindex of 34, co-authored 106 publications receiving 3701 citations. Previous affiliations of Ilya J. Finkelstein include Columbia University & University of Texas System.
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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jason J. Lavinder,Gregory C. Ippolito,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +23 more
TL;DR: High-yield production of a stabilized prefusion spike protein will accelerate the development of vaccines and serological diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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Human cohesin compacts DNA by loop extrusion
TL;DR: It is shown that in the presence of the NIPBLMAU2 protein complex, the human cohesin complex can function as a molecular motor that extrudes DNA loops with high speed in vitro and compacts DNA in an ATP-dependent manner.
Journal ArticleDOI
Frequency-frequency correlation functions and apodization in two-dimensional infrared vibrational echo spectroscopy: A new approach
TL;DR: A new observable is presented that greatly simplifies the extraction of the FFCF from experimental data that is the inverse of the center line slope (CLS) of the 2D spectrum and is essentially unaffected by Fourier filtering methods (apodization).
Posted ContentDOI
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes
Ching-Lin Hsieh,Jory A. Goldsmith,Jeffrey M. Schaub,Andrea M. DiVenere,Hung-Che Kuo,Kamyab Javanmardi,Kevin C. Le,Daniel Wrapp,Alison Gene-Wei Lee,Yutong Liu,Chia-Wei Chou,Patrick O. Byrne,Christy K. Hjorth,Nicole V. Johnson,John Ludes-Meyers,Annalee W. Nguyen,Juyeon Park,Nianshuang Wang,Dzifa Amengor,Jennifer A. Maynard,Ilya J. Finkelstein,Jason S. McLellan +21 more
TL;DR: Over 100 structure-guided spike variants based upon a previously determined cryo-EM structure of the prefusion SARS-CoV-2 spike are designed and expressed, with the best variant, HexaPro, having six beneficial proline substitutions leading to ∼10-fold higher expression than its parental construct.
Journal ArticleDOI
Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.
TL;DR: In this paper, the reaction steps of DNA targeting by acidaminococcus sp Cas12a (also known as Cpf1) were dissected using quantitative kinetics.