A
Amy Rump
Researcher at National Institutes of Health
Publications - 6
Citations - 360
Amy Rump is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immunology & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 286 citations.
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Journal ArticleDOI
Common Severe Infections in Chronic Granulomatous Disease
Beatriz E. Marciano,Christine Spalding,Alan Fitzgerald,Daphne Mann,Tom Brown,Sharon M. Osgood,Lynne Yockey,Dirk Darnell,Lisa A. Barnhart,Janine Daub,Lisa Boris,Amy Rump,Victoria L. Anderson,Carissa Haney,Douglas B. Kuhns,Sergio D. Rosenzweig,Corin Kelly,Adrian M. Zelazny,Tamika Mason,Suk See DeRavin,Elizabeth M. Kang,John I. Gallin,Harry L. Malech,Kenneth N. Olivier,Gulbu Uzel,Alexandra F. Freeman,Theo Heller,Christa S. Zerbe,Steven M. Holland +28 more
TL;DR: Fungal infections remain a major determinant of survival in CGD, and X-linked patients generally had more severe disease, and this was generally in those with lower residual superoxide production.
Journal ArticleDOI
Treatment With Anakinra, a Recombinant IL-1 Receptor Antagonist, Unlikely to Induce Lasting Remission in Patients With CGD Colitis.
Katherine J. Hahn,Nancy Ho,Lynne Yockey,Samantha Kreuzberg,Janine Daub,Amy Rump,Beatriz E. Marciano,Martha Quezado,Harry L. Malech,Steven M. Holland,Theo Heller,Christa S. Zerbe +11 more
TL;DR: Treatment With Anakinra, a Recombinant IL-1 Receptor Antagonist, Unlikely to Induce Lasting Remission in Patients With CGD Colitis.
Journal ArticleDOI
Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder.
Matthew K. Schindler,Stefania Pittaluga,Yoshimi Enose-Akahata,Helen C. Su,V. Koneti Rao,Amy Rump,Steven Jacobson,Irene Cortese,Daniel S. Reich,Gulbu Uzel +9 more
TL;DR: Neuroinflammation due to CTLA4h is mediated primarily by an infiltrative process with a distinct and striking dissociation between clinical symptoms and radiological findings in the majority of patients.
Journal ArticleDOI
Management of Cytopenias in CTLA4 Haploinsufficiency Using Abatacept and Sirolimus
Gulbu Uzel,Djuro Karanovic,Hua Su,Amy Rump,Anahita Agharahimi,Steven M. Holland,V. Koneti Rao +6 more
TL;DR: The experience with short and long term immunomodulatory therapy in treating autoimmune cytopenias in 22 patients with CTLA4 deficiency is shared, including the experience with off-label use of theCTLA4 mimetic, abatacept.
Journal ArticleDOI
Primary EBV Lymphoproliferative Disease Responsive to Therapy in a Patient with CTLA4-Haploinsufficiency
TL;DR: In this article , a 25-year male with Evans syndrome, hypogammaglobulinemia, and central nervous system vasculitis was evaluated for EBV-LPD in the setting of CTLA-4 haploinsufficiency.