E
Elizabeth M. Kang
Researcher at National Institutes of Health
Publications - 84
Citations - 3548
Elizabeth M. Kang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transplantation & Chronic granulomatous disease. The author has an hindex of 28, co-authored 74 publications receiving 3045 citations.
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Journal ArticleDOI
Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference
Adrianna Vlachos,Sarah E. Ball,Niklas Dahl,Blanche P. Alter,Sujit Sheth,Ugo Ramenghi,Joerg J Meerpohl,Stefan Karlsson,Johnson M. Liu,Thierry Leblanc,Carole Paley,Elizabeth M. Kang,Eva Judmann Leder,Eva Atsidaftos,Akiko Shimamura,Monica Bessler,Bertil Glader,Jeffrey M. Lipton +17 more
TL;DR: The criteria for diagnosis, available treatment options, including corticosteroid and transfusion therapies and stem cell transplantation, and a plan for optimizing patient care are reviewed.
Journal ArticleDOI
Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease
Matthew M. Hsieh,Elizabeth M. Kang,Courtney D. Fitzhugh,M. Beth Link,Charles D. Bolan,Roger Kurlander,Richard W. Childs,Griffin P. Rodgers,Jonathan D. Powell,John F. Tisdale +9 more
TL;DR: A protocol for nonmyeloablative allogeneic hematopoietic stem-cell transplantation that includes total-body irradiation and treatment with alemtuzumab and sirolimus can achieve stable, mixed donor-recipient chimerism and reverse the sickle cell phenotype.
Journal ArticleDOI
Common Severe Infections in Chronic Granulomatous Disease
Beatriz E. Marciano,Christine Spalding,Alan Fitzgerald,Daphne Mann,Tom Brown,Sharon M. Osgood,Lynne Yockey,Dirk Darnell,Lisa A. Barnhart,Janine Daub,Lisa Boris,Amy Rump,Victoria L. Anderson,Carissa Haney,Douglas B. Kuhns,Sergio D. Rosenzweig,Corin Kelly,Adrian M. Zelazny,Tamika Mason,Suk See DeRavin,Elizabeth M. Kang,John I. Gallin,Harry L. Malech,Kenneth N. Olivier,Gulbu Uzel,Alexandra F. Freeman,Theo Heller,Christa S. Zerbe,Steven M. Holland +28 more
TL;DR: Fungal infections remain a major determinant of survival in CGD, and X-linked patients generally had more severe disease, and this was generally in those with lower residual superoxide production.
Journal ArticleDOI
Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
Suk See De Ravin,Xiaolin Wu,Susan Moir,Lela Kardava,Sandra Anaya-O'Brien,Nana Kwatemaa,Patricia Littel,Narda Theobald,Uimook Choi,Ling Su,Martha Marquesen,Dianne Hilligoss,Janet Lee,Clarissa M. Buckner,Kol A. Zarember,Geraldine M. O’Connor,Daniel W. McVicar,Douglas B. Kuhns,Robert E. Throm,Sheng Zhou,Luigi D. Notarangelo,I. Celine Hanson,M.J. Cowan,Elizabeth M. Kang,Coleen Hadigan,Michael M Meagher,John T. Gray,Brian P. Sorrentino,Harry L. Malech +28 more
TL;DR: It is reported that lentiviral gene therapy with nonmyeloablative conditioning corrected multiple immune cell types in five older SCID-X1 patients whose symptoms persisted despite undergoing hematopoietic stem cell transplant(s) as infants.
Journal ArticleDOI
Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils
Elizabeth M. Kang,Uimook Choi,Narda Theobald,Gilda F. Linton,Debra A. Long Priel,Doug B Kuhns,Harry L. Malech +6 more
TL;DR: It is concluded that busulfan conditioning together with an MFGS vector is capable of achieving long-term correction of neutrophil oxidase function sufficient to provide benefit in management of severe infection.