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Amy Whitehead
Researcher at University of Southampton
Publications - 20
Citations - 2401
Amy Whitehead is an academic researcher from University of Southampton. The author has contributed to research in topics: Sample size determination & Population. The author has an hindex of 8, co-authored 18 publications receiving 1471 citations. Previous affiliations of Amy Whitehead include University Hospital Southampton NHS Foundation Trust & Southampton General Hospital.
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Journal ArticleDOI
Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable
TL;DR: This paper looks at how to choose an external pilot trial sample size in order to minimise the sample size of the overall clinical trial programme, that is, the pilot and the main trial together, and produces a method of calculating the optimal solution.
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An audit of sample sizes for pilot and feasibility trials being undertaken in the United Kingdom registered in the United Kingdom Clinical Research Network database
TL;DR: The target sample sizes set for pilot and feasibility randomised controlled trials, currently running within the United Kingdom, are described to describe the observed sample sizes in feasibility and pilot randomisedcontrolled trials on the UKCRN Database.
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Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study.
TL;DR: This work uses a simulation approach to illustrate the sampling distribution of the standard deviation for continuous outcomes and the event rate for binary outcomes, and presents the impact of increasing the pilot sample size on the precision and bias of these estimates, and predicted power under three realistic scenarios.
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The statistical interpretation of pilot trials: should significance thresholds be reconsidered?
TL;DR: It is shown how significance levels other than the traditional 5% should be considered to provide preliminary evidence for efficacy and how estimation and confidence intervals should be the focus to provide an estimated range of possible treatment effects.
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Pilot and feasibility studies: Is there a difference from each other and from a randomised controlled trial?
TL;DR: The term 'feasibility' should be used as an overarching term for preliminary studies and the term 'pilot' refers to a specific type of study which resembles the intended trial in aspects such as, having a control group and randomisation.