M. Dawn Teare

TL;DR: The results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma, and the latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.

TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.

TL;DR: This work uses a simulation approach to illustrate the sampling distribution of the standard deviation for continuous outcomes and the event rate for binary outcomes, and presents the impact of increasing the pilot sample size on the precision and bias of these estimates, and predicted power under three realistic scenarios.

TL;DR: This work provides an introduction to methods commonly used to map loci that predispose to disease and discusses the role of simulation in assessment of statistical significance and estimation of power.

TL;DR: It is demonstrated that JHF and ISH are allelic conditions and perturbation of basement-membrane matrix assembly as the cause of the characteristic perivascular hyaline deposition seen in these conditions.