Ana C. Bohórquez

TL;DR: It is demonstrated that internalized MNHs conjugated to EGF and which target the epidermal growth factor receptor do result in a significant reduction in cell viability and clonogenic survival in a thermal heat dose dependent manner, indicating that magnetic nanoparticles in alternating magnetic fields may effectively kill cancer cells under conditions previously considered as not possible.

TL;DR: Findings point to the opportunity of engineering MNPs for the selective destruction of cells and/or intracellular structures without the need for a macroscopic tissue temperature rise, in what is here call magnetically mediated energy delivery (MagMED).

TL;DR: In this article, an extended LaMer mechanism is proposed for fine size control in the synthesis of nanoparticles by establishing steady state growth conditions through the continuous, controlled addition of precursor, leading to a uniform rate of particle growth.

TL;DR: Improvements to the aqueous co-precipitation of iron oxide nanoparticles are focused on to increase the specific absorption rate (SAR) by optimizing synthesis conditions and the subsequent peptization step, which has great potential for application in nanoscale thermal cancer therapy.

TL;DR: The potential of magnetic activation to remotely control the TGF-β activity in vivo is highlighted, reducing the dangerous off-target side effects and offering a path to clinical implementation of this growth factor for regenerative medicine applications.