Mar Creixell

TL;DR: It is demonstrated that internalized MNHs conjugated to EGF and which target the epidermal growth factor receptor do result in a significant reduction in cell viability and clonogenic survival in a thermal heat dose dependent manner, indicating that magnetic nanoparticles in alternating magnetic fields may effectively kill cancer cells under conditions previously considered as not possible.

TL;DR: The use of nanocarriers to deliver siRNA, prevents both renal clearance and RNase degradation by protecting siRNA chains, increasing their half life in blood.

TL;DR: Both CMDx coated nanoparticles were equally effective in decreasing MCF-7 cancer cell viability by magnetic fluid hyperthermia (MFH), to levels of around 4–6%, compared to untreated samples, illustrating the importance of grafting method on obtaining nanoparticles suitable for biomedical applications.

TL;DR: Results showed that targeted magnetic nanoparticles were rapidly accumulated in both flask-shaped small vesicles and large circular endocytic structures, suggesting that both clathin-dependent and clathrin-independent receptors mediated endocytosis mechanisms are responsible for nanoparticle internalization.

TL;DR: This work provides a systemic comparison for ARGET ATRP and UV-initiated polycationic nanoparticles for drug delivery and a guide to deciding which type of polycationing nanoparticles have the best properties for specific applications.