Ana Maria de Oliveira

TL;DR: It is demonstrated that chemerin, through Nox activation and redox-sensitive mitogen-activated protein kinases signaling, exerts proapoptotic, proinflammatory, and proliferative effects in human vascular cells.

TL;DR: It is firstly demonstrated functionally the existence of both ETA and ETB vasoconstrictor receptors located on the smooth muscle of rat carotid arteries and endothelial ETB receptors that mediated vasorelaxation via NO–cGMP pathway, vasodilator cyclooxygenase product(s) and the activation of voltage‐dependent K+ channels.

TL;DR: Functional evidence is provided that the effects elicited by the hidroalcoholic extract of Pimpinella anisum involve the participation of NO and subsequent activation of the NO-cGMP pathway and justifies its use in the folk medicine as an antispasmodic agent.

TL;DR: The mechanisms underlying the hypotensive action displayed by diterpenes and their potential use in human hypertension are discussed and the use of these compounds in the treatment of glaucoma is discussed, which is characterized by increased intraocular pressure (IOP).

TL;DR: In this article, the authors describe the mechanisms involved in the vasorelaxant effect of the diterpene ent-kaur-16-en-19-oic acid (kaurenoic acid).