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Ana Rilak
Researcher at University of Kragujevac
Publications - 11
Citations - 612
Ana Rilak is an academic researcher from University of Kragujevac. The author has contributed to research in topics: Terpyridine & Ruthenium. The author has an hindex of 10, co-authored 11 publications receiving 470 citations. Previous affiliations of Ana Rilak include University of Trieste.
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Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives
TL;DR: This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
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New 4'-(4-chlorophenyl)-2,2':6',2″-terpyridine ruthenium(II) complexes: Synthesis, characterization, interaction with DNA/BSA and cytotoxicity studies.
Milan M. Milutinović,Ana Rilak,Ioannis Bratsos,Olivera R. Klisurić,Milan Vraneš,Nevenka Gligorijević,Siniša Radulović,Živadin D. Bugarčić +7 more
TL;DR: These experiments show that the ruthenium complexes interact with DNA via intercalation, and can displace DNA-bound EB, suggesting strong competition with EB.
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New water-soluble ruthenium(II) terpyridine complexes for anticancer activity: synthesis, characterization, activation kinetics, and interaction with guanine derivatives.
Ana Rilak,Ioannis Bratsos,Ennio Zangrando,Jakob Kljun,Iztok Turel,Živadin D. Bugarčić,Enzo Alessio +6 more
TL;DR: The complexes with bidentate aliphatic diamines proved to be superior to those with bpy in terms of solubility and reactivity (i.e., release of Cl(-) and capability to bind guanine derivatives).
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DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(II) terpyridine complexes
TL;DR: The results indicate that these complexes can bind to DNA covalently and non-covalently, and only compounds that hydrolyze the monodentate ligand at a reasonable rate show moderate activity.
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Factors that influence the antiproliferative activity of half sandwich RuII–[9]aneS3 coordination compounds: activation kinetics and interaction with guanine derivatives
Ana Rilak,Ana Rilak,Ioannis Bratsos,Ennio Zangrando,Jakob Kljun,Iztok Turel,Živadin D. Bugarčić,Enzo Alessio +7 more
TL;DR: TheKinetics of aquation and anation of complexes 2 and 3, as well as the kinetics and the mechanism of the reaction of complexes 1-3 with the biologically more relevant 5'-GMP ligand were studied by UV-Vis spectroscopy and support an associative mechanism for the substitution process.