Anders Valind

TL;DR: It is found that microdiversity predicts poor cancer-specific survival (60%; P=0.009), independent of other risk factors, in a cohort of 44 patients with chemotherapy-treated childhood kidney cancer, and survival was 100% for patients lacking microd diversity.

TL;DR: Multiregional analysis in 54 childhood cancers highlights four evolutionary patterns of intratumoral variation, suggesting that tumors follow different evolutionary strategies concurrently.

TL;DR: It is shown that YWHAE–NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems that have important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis.

TL;DR: In line with TERT expression being driven by active IRX2 regulatory elements, it is concluded that in addition to promoter mutations and epigenetic events, TERT can also be activated in tumors via formation of fusion transcripts.

TL;DR: It is shown that aneuploidy does not, on its own, lead to chromosomal instability, even when cells acquire chromosome alterations typical of cancer, and that constitutional trisomy, even for large chromosomes that are often trisomic in cancer, does not confer a significantly elevated rate of somatic chromosomal mosaicism in individual cases.