A
Anders Valind
Researcher at Lund University
Publications - 28
Citations - 357
Anders Valind is an academic researcher from Lund University. The author has contributed to research in topics: Chromosome instability & Wilms' tumor. The author has an hindex of 8, co-authored 23 publications receiving 267 citations.
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Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer
Linda Holmquist Mengelbier,Jenny Karlsson,David Lindgren,Anders Valind,Henrik Lilljebjörn,Caroline Jansson,Daniel Bexell,Noémie Braekeveldt,Adam Ameur,Tord Jonson,Hanna Göransson Kultima,Anders Isaksson,Jurate Asmundsson,Rogier Versteeg,Marianne Rissler,Thoas Fioretos,Bengt Sandstedt,Anna Börjesson,Torbjörn Backman,Niklas Pal,Ingrid Øra,Markus Mayrhofer,David Gisselsson +22 more
TL;DR: It is found that microdiversity predicts poor cancer-specific survival (60%; P=0.009), independent of other risk factors, in a cohort of 44 patients with chemotherapy-treated childhood kidney cancer, and survival was 100% for patients lacking microd diversity.
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Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
Jenny Karlsson,Anders Valind,Linda Holmquist Mengelbier,Sofia Bredin,Louise Cornmark,Caroline Jansson,Amina Wali,Johan Staaf,Björn Viklund,Ingrid Øra,Anna Börjesson,Torbjörn Backman,Noémie Braekeveldt,Bengt Sandstedt,Niklas Pal,Anders Isaksson,Barbara Gürtl Lackner,Tord Jonson,Daniel Bexell,David Gisselsson +19 more
TL;DR: Multiregional analysis in 54 childhood cancers highlights four evolutionary patterns of intratumoral variation, suggesting that tumors follow different evolutionary strategies concurrently.
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BCOR internal tandem duplication and YWHAE–NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney
TL;DR: It is shown that YWHAE–NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems that have important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis.
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Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.
Jenny Karlsson,Henrik Lilljebjörn,Linda Holmquist Mengelbier,Anders Valind,Marianne Rissler,Ingrid Øra,Thoas Fioretos,David Gisselsson +7 more
TL;DR: In line with TERT expression being driven by active IRX2 regulatory elements, it is concluded that in addition to promoter mutations and epigenetic events, TERT can also be activated in tumors via formation of fusion transcripts.
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Whole chromosome gain does not in itself confer cancer-like chromosomal instability
TL;DR: It is shown that aneuploidy does not, on its own, lead to chromosomal instability, even when cells acquire chromosome alterations typical of cancer, and that constitutional trisomy, even for large chromosomes that are often trisomic in cancer, does not confer a significantly elevated rate of somatic chromosomal mosaicism in individual cases.