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Andras Kapus
Researcher at University of Toronto
Publications - 145
Citations - 10462
Andras Kapus is an academic researcher from University of Toronto. The author has contributed to research in topics: Phosphorylation & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 57, co-authored 137 publications receiving 9729 citations. Previous affiliations of Andras Kapus include University Health Network & Toronto General Hospital.
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Membrane phosphatidylserine regulates surface charge and protein localization
TL;DR: A biosensor developed to study the subcellular distribution of phosphatidylserine found that it binds the cytosolic leaflets of the plasma membrane, as well as endosomes and lysosomes.
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Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
TL;DR: PBEF is identified as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis and is also upregulated in neutrophils by IL-1beta and functions as an inhibitor of apoptosis in response to a variety of inflammatory stimuli.
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Receptor Activation Alters Inner Surface Potential During Phagocytosis
Tony Yeung,Mauricio R. Terebiznik,Liming Yu,John R. Silvius,Wasif M. Abidi,Mark R. Philips,Tim P. Levine,Andras Kapus,Sergio Grinstein +8 more
TL;DR: These probes revealed marked, localized alterations in the charge of the inner surface of the plasma membrane of macrophages during the course of phagocytosis, which accounted for the change in surface potential at the phagosomal cup.
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Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway
Xiao-Han Zhao,Carol Laschinger,Pam Arora,Katalin Szászi,Andras Kapus,Christopher A. McCulloch +5 more
TL;DR: Mechanical forces mediate actin assembly through the Rho–Rho-kinase–LIMK cofilin pathway, which promotes nuclear translocation of MRTF and subsequent activation of the SMA promoter to enhance SMA expression in fibroblasts.
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Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance
TL;DR: CD36-dependent binding and signaling appears to be crucial for the nonopsonic clearance of PEs and does not appear to contribute to the increase in TNF-alpha that is prognostic of poor outcome in clinical malaria.