M
Mauricio R. Terebiznik
Researcher at University of Toronto
Publications - 51
Citations - 3033
Mauricio R. Terebiznik is an academic researcher from University of Toronto. The author has contributed to research in topics: Phagosome & Phagocytosis. The author has an hindex of 25, co-authored 47 publications receiving 2725 citations. Previous affiliations of Mauricio R. Terebiznik include University of Buenos Aires & Facultad de Ciencias Exactas y Naturales.
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Journal ArticleDOI
Receptor Activation Alters Inner Surface Potential During Phagocytosis
Tony Yeung,Mauricio R. Terebiznik,Liming Yu,John R. Silvius,Wasif M. Abidi,Mark R. Philips,Tim P. Levine,Andras Kapus,Sergio Grinstein +8 more
TL;DR: These probes revealed marked, localized alterations in the charge of the inner surface of the plasma membrane of macrophages during the course of phagocytosis, which accounted for the change in surface potential at the phagosomal cup.
Journal ArticleDOI
Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation
Nicolas Touret,Paul Paroutis,Mauricio R. Terebiznik,Rene E. Harrison,Sergio Trombetta,Marc Pypaert,Amy Y. M. Chow,Aimin Jiang,James E. Shaw,Christopher M. Yip,Hsiao-Ping H. Moore,Nicole N. van der Wel,Diane Houben,Peter J. Peters,Chantal de Chastellier,Ira Mellman,Sergio Grinstein +16 more
TL;DR: The data indicate that the plasma membrane is the main constituent of nascent and newly formed phagosomes, which are progressively remodeled by fusion with endosomal and eventually lysosomal compartments as phagosome mature into acidic, degradative organelles.
Journal ArticleDOI
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.
Mauricio R. Terebiznik,Otilia V. Vieira,Sandra L. Marcus,Andrea Slade,Christopher M. Yip,William S. Trimble,Tobias Meyer,B. Brett Finlay,Sergio Grinstein +8 more
TL;DR: It is shown that the outermost parts of the ruffles induced by invasion show a modest enrichment in PtdIns(4,5)P2, but that Ptd insurance is virtually absent from the invaginating regions.
Matters Arising Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation
Nicolas Touret,Paul Paroutis,Mauricio R. Terebiznik,Rene E. Harrison,Sergio Trombetta,Marc Pypaert,Amy Y. M. Chow,Aimin Jiang,James E. Shaw,Christopher M. Yip,Hsiao-Ping H. Moore,Nicole N. van der Wel,Diane Houben,Peter J. Peters,Chantal de Chastellier,Ira Mellman,Sergio Grinstein +16 more
TL;DR: Gagnon et al. as discussed by the authors used a combination of biochemical,fluorescence imaging, and electron microscopy tech-niques to quantitatively and dynamically assess the contribution of the plasmalemma and of the endoplasmic reticu-lum (ER) to phagosome formation and maturation.
Journal ArticleDOI
SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34
Gustavo V. Mallo,Marianela Espina,Adam C. Smith,Mauricio R. Terebiznik,Ainel Alemán,B. Brett Finlay,Lucia E. Rameh,Sergio Grinstein,John H. Brumell +8 more
TL;DR: It is revealed that SopB mediates PI(3)P production on the SCV indirectly through recruitment of Rab5 and its effector Vps34 and a link between phosphoinositide phosphatase activity and the recruited Rab5 to phagosomes is revealed.