András Micsonai

TL;DR: This work has developed a method called β-structure selection (BeStSel) for the secondary structure estimation that takes into account the twist of β-structures, and can predict the protein fold down to the topology level following the CATH classification from a single CD spectrum.

TL;DR: It is shown that the orientation and twisting of β-sheets account for the observed spectral diversity, and a new method to estimate accurately the secondary structure is developed, and the originality of BeStSel is that it carries out a detailed secondary structure analysis.

TL;DR: The results unveiled that C1q label-based synaptic pruning is triggered by and directly linked to apoptotic-like processes in the synaptic compartment, which was confirmed experimentally with apoptosis markers.

TL;DR: The thermal stability and heat-induced depolymerization of amyloid fibrils of β(2)-microglobulin (β2m), a protein responsible for dialysis-related amyloidsosis, is studied and the effects of some additives and different factors on the stability ofAmyloid Fibrils are investigated.

TL;DR: A brief step-by-step guide to record the CD spectra of proteins and their analysis with the BeStSel method, which provides an improved β-structure determination and its performance is more accurate for any of the secondary structure types compared to previous CD spectrum analysis algorithms.