Helton C. Santiago

TL;DR: The results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and thatTLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-γ synthesis during infection with T. cruzi.

TL;DR: Assessment of the safety and immunogenicity of recombinant Na-ASP-2 adjuvanted with Alhydrogel in healthy Brazilian adults previously infected with N americanus highlighted the important differences between the immune responses to natural helminth infection and to vaccination with a recombinanthelminth antigen.

TL;DR: The results indicate that the distribution of T-cell subsets in the myocardium of T. cruzi -infected mice reflects the particular profile of adhesion molecules acquired by most peripheral CD8 + T lymphocytes and point to the possibility that multiple IFN-γ-inducible molecules present in the inflamed tissue contribute to the establishment and maintenance of T Cruzi -induced myocarditis.

TL;DR: This first trial of a human hookworm vaccine demonstrates that the Na-ASP-2 vaccine is well-tolerated and induces a prolonged immune response in adults not exposed to hookworm, justifying further testing of this vaccine in an endemic area.

TL;DR: In vitro studies revealed that IFN-γ-stimulated LRG-47 KO macrophages display defective intracellular killing of amastigotes despite normal expression of TNF and NO synthetase type 2 and that both NO Synthetasetype 2 and LRg-47 are required for optimum IFN -γ-dependent restriction of parasite growth.