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André Bensadoun
Researcher at Cornell University
Publications - 151
Citations - 11432
André Bensadoun is an academic researcher from Cornell University. The author has contributed to research in topics: Lipoprotein lipase & GPIHBP1. The author has an hindex of 53, co-authored 151 publications receiving 10986 citations. Previous affiliations of André Bensadoun include University of California, San Diego & University of California, San Francisco.
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Journal ArticleDOI
Genetics and molecular biology of hepatic lipase.
TL;DR: Hepatic lipase is emerging as a major factor in the control of HDL metabolism and may enhance the uptake of lipoproteins by cell surface receptors, according to recent information.
Journal ArticleDOI
Identification of mouse and human macrophages as a site of synthesis of hepatic lipase
Herminia González-Navarro,Zengxuan Nong,Lita A. Freeman,André Bensadoun,Katherine Peterson,Silvia Santamarina-Fojo +5 more
TL;DR: It is established that HL is synthesized de novo by macrophages as well as liver, and the possibility that HL may have a direct role in the pathogenesis of atherosclerosis is raised.
Journal ArticleDOI
Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1
Constance V. Voss,Brandon S.J. Davies,Shelly Tat,Peter Gin,Loren G. Fong,Christopher Pelletier,Charlene D. Mottler,André Bensadoun,Anne P. Beigneux,Stephen G. Young +9 more
TL;DR: This work reports that two LPL missense mutations initially identified in patients with chylomicronemia, C418Y and E421K, abolish LPL's ability to bind to GPIHBP1 without interfering with LPL catalytic activity or binding to heparin.
Journal ArticleDOI
Effect of chlorate on the sulfation of lipoprotein lipase and heparan sulfate proteoglycans. Sulfation of heparan sulfate proteoglycans affects lipoprotein lipase degradation.
TL;DR: It is shown that decreased sulfation of heparan sulfate proteoglycans decreases the maximum binding of the lipase for the adipocyte cell surface and that chlorate inhibits lipoprotein lipase sulfation and that desulfation of the enzyme has no effect on its catalytic efficiency or on its binding to cultured adipocytes.
Journal ArticleDOI
Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase.
Anne P. Beigneux,Brandon S.J. Davies,Shelly Tat,Jenny Chen,Peter Gin,Constance V. Voss,Michael M. Weinstein,André Bensadoun,Clive R. Pullinger,Loren G. Fong,Stephen G. Young +10 more
TL;DR: It is demonstrated that the Ly6 domain of GPIHBP1 is important for the ability of GPL binding and transport LPL, and 12 amino acids within GPIhBP1 that are important for LPL binding are identified.