André Bensadoun

TL;DR: Findings show that under normal physiological conditions, hepatic heparan sulfate proteoglycans play a crucial role in the clearance of both intestinally derived and hepatic lipoprotein particles.

TL;DR: Study of the effects of pioglitazone (Pio), a PPARγ agonist that improves insulin sensitivity, on lipoprotein metabolism in patients with T2DM found increased lipolysis of VLDL TGs during Pio treatment, supported by the finding of increased plasma LPL mass and decreased levels of plasma apoC-III.

TL;DR: The hypertriglyceridemic effect of Angptl4 is attributable to inhibition of LPL-dependent VLDL lipolysis by converting LPL dimers to monomers, and AngPTl4 upregulates cholesterol synthesis in liver secondary to inhibitionof L PL- and HL-dependent hepatic cholesterol uptake.

TL;DR: Equilibrium-binding data of highly purified avian lipoprotein lipase to cultured bovine endothelial cells demonstrate the presence of a class of high affinity sites and the demonstration that the preparation utilized contained no detectable protease activity is further evidence that lipop protein lipase is bound to endothelial cell heparan sulfate or heparAn sulfate-like molecules.

TL;DR: A homozygous missense mutation in GPIHBP1 (Q115P) was identified in a 33-year-old male with lifelong chylomicronemia, strongly suggesting that it caused the patient’s chylomaticronemia.