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André Bensadoun
Researcher at Cornell University
Publications - 151
Citations - 11432
André Bensadoun is an academic researcher from Cornell University. The author has contributed to research in topics: Lipoprotein lipase & GPIHBP1. The author has an hindex of 53, co-authored 151 publications receiving 10986 citations. Previous affiliations of André Bensadoun include University of California, San Diego & University of California, San Francisco.
Papers
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Journal ArticleDOI
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells.
Brandon S.J. Davies,Chris N. Goulbourne,Richard H. Barnes,Kirsten A. Turlo,Peter Gin,Sue Vaughan,David J. Vaux,André Bensadoun,Anne P. Beigneux,Loren G. Fong,Stephen G. Young +10 more
TL;DR: The studies show that GPIHBP1 and LPL move bidirectionally across endothelial cells in vesicles and that transport is efficient even when caveolin-1 is absent, which is consistent with a vesicular transport process.
Journal ArticleDOI
Purification, stabilization, and characterization of rat hepatic triglyceride lipase.
Gordon L. Jensen,André Bensadoun +1 more
TL;DR: The use of DEAE chromatography and stabilization of H-TGL with Triton N-101 are the improvements in purification that resulted in an 8-fold enhancement in specific activity relative to the highest previous report of purification from rat liver perfusates.
Journal ArticleDOI
In Vivo Evidence for Both Lipolytic and Nonlipolytic Function of Hepatic Lipase in the Metabolism of HDL
Klaus A. Dugi,Marcelo Amar,Changting Haudenschild,Robert D. Shamburek,André Bensadoun,Robert F. Hoyt,Jamila Fruchart-Najib,Z. Madj,H B Brewer,Silvia Santamarina-Fojo +9 more
TL;DR: The combined findings demonstrate that both lipolytic and nonlipolytic functions of HL are important for HDL metabolism in vivo and provides new insights into the role of HL in facilitating distinct metabolic pathways involved in the catabolism of apOA-I- versus apoA-II-containing HDL.
Journal ArticleDOI
Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase.
TL;DR: Several epitopes of the hepatic triglyceride lipase protein moiety are not present in the lipoprotein lipase molecule, strongly supporting the view that the two enzymes are different proteins.
Journal ArticleDOI
In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity.
TL;DR: Evidence in humans is provided that HL indeed plays an important role in lipoprotein metabolism independent of its enzymatic activity: in particular, inactive HL protein appears to affect VLDL and IDL particle concentration, whereas HL enzymatics activity seems to influence V LDL-, IDL-, LDL-, and HDL-TG content and their physical properties.