Disposable sensors are low-cost and easy-to-use sensing devices intended for short-term or rapid single-point measurements. The growing demand for fast, accessible, and reliable information in a vastly connected world makes disposable sensors increasingly important. The areas of application for such devices are numerous, ranging from pharmaceutical, agricultural, environmental, forensic, and food sciences to wearables and clinical diagnostics, especially in resource-limited settings. The capabilities of disposable sensors can extend beyond measuring traditional physical quantities (for example, temperature or pressure); they can provide critical chemical and biological information (chemo- and biosensors) that can be digitized and made available to users and centralized/decentralized facilities for data storage, remotely. These features could pave the way for new classes of low-cost systems for health, food, and environmental monitoring that can democratize sensing across the globe. Here, a brief insight into the materials and basics of sensors (methods of transduction, molecular recognition, and amplification) is provided followed by a comprehensive and critical overview of the disposable sensors currently used for medical diagnostics, food, and environmental analysis. Finally, views on how the field of disposable sensing devices will continue its evolution are discussed, including the future trends, challenges, and opportunities.

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Disposable Sensors in Diagnostics, Food, and Environmental Monitoring.

Electrically–transduced sensors, with their simplicity and compatibility with standard electronic technologies, produce signals that can be efficiently acquired, processed, stored, and analyzed. Two dimensional (2D) nanomaterials, including graphene, phosphorene (BP), transition metal dichalcogenides (TMDCs), and others, have proven to be attractive for the fabrication of high–performance electrically-transduced chemical sensors due to their remarkable electronic and physical properties originating from their 2D structure. This review highlights the advances in electrically-transduced chemical sensing that rely on 2D materials. The structural components of such sensors are described, and the underlying operating principles for different types of architectures are discussed. The structural features, electronic properties, and surface chemistry of 2D nanostructures that dictate their sensing performance are reviewed. Key advances in the application of 2D materials, from both a historical and analytical pers...

Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials

Sensors based on the detection of small resistance variations are universally recognized as piezoresistive. Being one of the simplest, most common and most investigated classes of sensors, continuous efforts are focused on creating improved devices with higher performance that can be used in many commercial and non–commercial applications (e.g. evaluation of strain, pressure, acceleration, force etc.). Consequently, despite the fact that more than 150 years have passed since the discovery of the piezoresistive effect in some classes of metals and semiconductors, the development of such sensors remains interesting and topical. Moreover, with the advent of second–generation robotics, research on piezoresistive sensors has undergone a massive increase. This paper aims to be a short, self–consistent vademecum which would be useful to researchers and engineers, since it focuses on the fundamentals of theory, materials, and readout–circuit design pertinent to the most recent developments in the field of piezoresistive sensors.

Theory, technology and applications of piezoresistive sensors: A review

Modern gas sensor technology is becoming an important part of our lives. It has been applied within the home (monitoring CO levels from boilers), the workplace (e.g., checking levels of toxic gases) to healthcare (monitoring gases in hospitals). However, historically the high price of gas sensors has limited market penetration to niche applications, such as safety in mines or petrochemical plants. The high price may be attributed to several different components: (1) cost of a predominantly manual manufacturing process; (2) need for interface circuitry in the form of discrete components on a PCB; and (3) fireproof packaging, making the cost of gas detection instruments typically many hundreds of dollars. Consequently, there has been a considerable effort over the past 20 years, towards the goal of low-cost ($1-$5) gas sensors, employing modern microelectronics technology to manufacture both the sensing element and the signal conditioning circuitry on a single silicon chip. In this paper, we review the emerging field of CMOS gas sensors and focus upon the integration of two main gas-sensing principles, namely, resistive and electrochemical and associated circuitry by CMOS technology. We believe that the combination of CMOS technology with more recent MEMS processing is now mature enough to deliver the exacting demands required to make low-power, low-cost smart gas sensors in high volume and this should result in a new generation of CMOS gas sensors. These new integrated, mass-produced gas sensors could open up mass markets and affect our everyday lives through application in cars, cell phones, watches, etc.

CMOS Interfacing for Integrated Gas Sensors: A Review

Electronic noses have potential applications in daily life, but are restricted by their bulky size and high price. This review focuses on the use of chemiresistive gas sensors, metal-oxide semiconductor gas sensors and conductive polymer gas sensors in an electronic nose for system integration to reduce size and cost. The review covers the system design considerations and the complementary metal-oxide-semiconductor integrated technology for a chemiresistive gas sensor electronic nose, including the integrated sensor array, its readout interface, and pattern recognition hardware. In addition, the state-of-the-art technology integrated in the electronic nose is also presented, such as the sensing front-end chip, electronic nose signal processing chip, and the electronic nose system-on-chip.

https://www.mdpi.com/1424-8220/13/10/14214/pdf

Towards a Chemiresistive Sensor-Integrated Electronic Nose: A Review

Introduction.- 1. Physical and Chemical Sensors.- 2. Resistive, Capacitive and Temperature Sensor Interfacing Overview.- 3. The Voltage-mode Approach in Sensor Interfaces Design.- 4. The Current-mode Approach in Sensor Interfaces Design.- 5. Detection of Small and Noisy Signals in Sensor Interfacing: The Analog Lock-in Amplifier.- A1. The Second Generation Current-Conveyor (CCII).- A2. Noise and Offset Compensation Techniques.

Analog Circuits and Systems for Voltage-Mode and Current-Mode Sensor Interfacing Applications

Less than thirty years after the giant magnetoresistance (GMR) effect was described, GMR sensors are the preferred choice in many applications demanding the measurement of low magnetic fields in small volumes. This rapid deployment from theoretical basis to market and state-of-the-art applications can be explained by the combination of excellent inherent properties with the feasibility of fabrication, allowing the real integration with many other standard technologies. In this paper, we present a review focusing on how this capability of integration has allowed the improvement of the inherent capabilities and, therefore, the range of application of GMR sensors. After briefly describing the phenomenological basis, we deal on the benefits of low temperature deposition techniques regarding the integration of GMR sensors with flexible (plastic) substrates and pre-processed CMOS chips. In this way, the limit of detection can be improved by means of bettering the sensitivity or reducing the noise. We also report on novel fields of application of GMR sensors by the recapitulation of a number of cases of success of their integration with different heterogeneous complementary elements. We finally describe three fully functional systems, two of them in the bio-technology world, as the proof of how the integrability has been instrumental in the meteoric development of GMR sensors and their applications.

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Integration of GMR Sensors with Different Technologies.

SUMMARY

In this paper, we propose a novel current-mode solution suitable for the square waveform generation. The designed oscillator, which utilizes only two positive second-generation current conveyors as active blocks, six resistors and a capacitor, is based on a current differentiation, instead of voltage integration, typical of developed solutions both in voltage-mode and in current-mode approaches, so avoiding circuit limitations due to the node saturation effects. The proposed circuit has been designed, as an integrated solution at transistor level, in a standard CMOS technology, with low-voltage (± 1V) and low-power (430µW) characteristics. Simulation results have confirmed the good circuit behaviour, also for working temperature drifts, showing good linearity in a wide oscillation frequency range, which can be independently adjusted through either capacitive (in the range pF − µF) or resistive (in the range M Ω–G Ω) external passive components. Waiting for the chip fabrication, preliminary measurements have been performed using a laboratory breadboard employing the CCII with AD844 commercial component and sample capacitors and resistors. The experimental results have shown good agreement with both simulations and theoretical expectations. Copyright © 2011 John Wiley & Sons, Ltd.

A CCII-based wide frequency range square waveform generator

A new current mode building block named voltage and current gain second generation current conveyor (VCG-CCII) is introduced. The voltage and current buffers of the standard CCII are replaced by voltage and current amplifiers with tunable gains so to obtain an extremely flexible and versatile building block. The VCG-CCII can be used in place of the standard CCII in impedance conversion applications so to utilize only one active component. A circuit implementation in a standard 0.35 μm CMOS process is presented and used to multiply, as an example, a 10 pF capacitor by a factor tunable from 1 up to about 3100, achieving a capacitance multiplication for more than 6 decades frequency range (from 0.15 to 865 KHz for the highest multiplication factor).

The VCG-CCII: a novel building block and its application to capacitance multiplication

In this paper, we propose novel fully analog uncalibrated readout circuits for wide-range capacitance estimation. The working principle is based on a modified De-Sauty ac bridge configuration where two capacitances and two resistances are employed. Through the use of a voltage controlled resistor and of a suitable feedback loop, an accurate estimation over a wide range of the sensor capacitance variation is possible, also without the knowledge of the other bridge component values. The first two proposed solutions are able to estimate, experimentally, ~1.5 decades (optimized range: [25-840 nF]) and more than 3 decades [900 pF-1.1 μF] of capacitive variations, respectively, ensuring, continuously, the bridge equilibrium condition; the third interface allows the evaluation of the sensor capacitance also outside this condition, increasing the capacitive variation decades to more than 4 [81 pF-1.1 μF]. The proposed topologies have been also modified to detect the capacitive sensor parasitic resistance. In this case, experimental results on PCB have demonstrated the capability to simultaneously estimate ~ 1.7 capacitive [2-100 nF] and 1.5 resistive variation decades [33 kΩ-1.2 MΩ]. Finally, a suitable optimization of the operating range of the first proposed solution, obtained through a proper passive components sizing, has been performed with the aim to employ the commercial humidity sensor HCH-1000 in a high accuracy (11.4 bits) RH% detection.

Andrea De Marcellis

Papers

Analog Circuits and Systems for Voltage-Mode and Current-Mode Sensor Interfacing Applications

Integration of GMR Sensors with Different Technologies.

A CCII-based wide frequency range square waveform generator

The VCG-CCII: a novel building block and its application to capacitance multiplication

Novel Modified De-Sauty Autobalancing Bridge-Based Analog Interfaces for Wide-Range Capacitive Sensor Applications