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Andrea J. Kriz
Researcher at Massachusetts Institute of Technology
Publications - 10
Citations - 6016
Andrea J. Kriz is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cas9 & Genome. The author has an hindex of 8, co-authored 9 publications receiving 5433 citations.
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In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran,Le Cong,Winston X. Yan,David A. Scott,Jonathan S. Gootenberg,Andrea J. Kriz,Bernd Zetsche,Ophir Shalem,Xuebing Wu,Kira S. Makarova,Eugene V. Koonin,Phillip A. Sharp,Feng Zhang +12 more
TL;DR: In this paper, the RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform and has been used for basic research and therapeutic applications that use the highly versatile adeno-associated virus (AAV) delivery vehicle.
Journal ArticleDOI
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran,Le Cong,Winston X. Yan,David A. Scott,Jonathan S. Gootenberg,Andrea J. Kriz,Bernd Zetsche,Ophir Shalem,Xuebing Wu,Kira S. Makarova,Eugene V. Koonin,Phillip A. Sharp,Feng Zhang +12 more
TL;DR: Six smaller Cas9 orthologues are characterized and it is shown that Cas9 from Staphylococcus aureus (SaCas9) can edit the genome with efficiencies similar to those of SpCas9, while being more than 1 kilobase shorter.
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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Xuebing Wu,David A. Scott,Andrea J. Kriz,Anthony C. Chiu,Patrick D. Hsu,Daniel B. Dadon,Albert W. Cheng,Alexandro E. Trevino,Silvana Konermann,Sidi Chen,Rudolf Jaenisch,Feng Zhang,Phillip A. Sharp +12 more
TL;DR: A two-state model for Cas9 binding and cleavage is proposed, in which a seed match triggers binding but extensive pairing with target DNA is required for cleavage.
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Xuebing Wu,Albert W. Cheng,Sidi Chen,Rudolf Jaenisch,Feng Zhang,Anthony C. Chiu,Phillip A. Sharp,David Scott,Patrick D. Hsu,Alexandro E. Trevino,Silvana Konermann,Andrea J. Kriz,Daniel B. Dadon +12 more
Journal ArticleDOI
Promoter directionality is controlled by U1 snRNP and polyadenylation signals
TL;DR: In this paper, the authors show that asymmetric sequence determinants flanking gene transcription start sites control promoter directionality by regulating promoter-proximal cleavage and polyadenylation.